| Name | Character | Episodes |
|---|---|---|
| Amanda Crew | Carrie Miller | 26 |
| Christopher Shyer | Adrien Varland | 26 |
| Jesse Moss | Quinn McKaye | 26 |
| Adam J. Harrington | Ryan McKaye | 26 |
| David Paetkau | Beck McKaye | 26 |
| Tamara Hope | Leah Hutton | 26 |
| Holly Dignard | Nicole Miller | 26 |
| Kim Hawthorne | Jada Temple | 26 |
| Ingrid Kavelaars | Jen Mckaye | 26 |
| Diego Klattenhoff | Derek | 13 |
| Nicholas Lea | Ethan McKaye | 13 |
| Peter Outerbridge | Peter Varland | 6 |
| Brandy Ledford | 5 | |
| Steve Bacic | 3 | |
| Chelah Horsdal | 2 | |
| Benjamin Ayres | 2 | |
| Kandyse McClure | 2 | |
| Tyron Leitso | 2 | |
| John Mann | 2 | |
| Veena Sood | 2 | |
| Nicole McKay | 2 | |
| Christopher Heyerdahl | Justin Talbert | 1 |
| Christine Chatelain | 1 | |
| Michael Eklund | 1 | |
| Valerie Tian | 1 | |
| Venus Terzo | 1 | |
| Cory Monteith | 1 | |
| Jessica Harmon | 1 | |
| Meghan Heffern | 1 | |
| Amber Borycki | 1 | |
| Lindsay Maxwell | 1 | |
| Sonja Bennett | Kate Judson | 1 |