| Name | Character | Episodes |
|---|---|---|
| Awkwafina | Nora Lin | 27 |
| BD Wong | Wally | 27 |
| Lori Tan Chinn | Grandma | 27 |
| Bowen Yang | Edmund | 17 |
| Jennifer Esposito | Brenda | 14 |
| Jonathan Park | Doug | 6 |
| Wai Ching Ho | Li-Wei | 5 |
| Chrissie Fit | Melanie | 5 |
| Jaboukie Young-White | Daniel | 3 |
| Woody Fu | Mr. Moon | 3 |
| Harry Zittel | Patrick | 3 |
| Celia Au | Grace | 2 |
| Ajay Mehta | Callisto | 2 |
| Ross Butler | Chuck | 2 |
| Stephanie Hsu | Shu Shu | 2 |
| Scott Adsit | Constantine | 2 |
| Michael Bolton | Kevin | 2 |
| Kerri Kenney | Phobos | 2 |
| Fortune Feimster | Deimos | 2 |
| Michelle Buteau | Margaret | 2 |
| Margaret Cho | Mistress Jupiter | 2 |
| Tom Beyer | Gas Station Attendant | 2 |
| Lea DeLaria | Alfur the Elf | 2 |
| Jai Rodriguez | Detective Johnson | 2 |
| John Sanders | Tom | 2 |
| Chris Gethard | Toby | 2 |
| Randy Kovitz | George | 2 |
| Preston Christopher Lawrence | Andrei's Bodyguard | 2 |
| Haley Joel Osment | Amos | 1 |
| Gina Gershon | Toe / Dr. Emily Cohen | 1 |
| Ming-Na Wen | Aunt Sandra | 1 |
| Alex Borstein | Wilma (voice) | 1 |
| Jamie Chung | Young Grandma | 1 |
| Simu Liu | Garbage Boy | 1 |
| Natasha Lyonne | Woman in Hair Salon | 1 |
| David Krumholtz | Jerry Harrison | 1 |
| Harry Shum Jr. | Doc Hottie | 1 |
| Janeane Garofalo | Carol | 1 |
| Ken Jeong | Dave Lee | 1 |
| C.S. Lee | Wayne | 1 |
| Cindy Cheung | Susan | 1 |
| Ronny Chieng | Arthur | 1 |
| Chloe Fineman | Greta | 1 |
| Peter Mark Kendall | Rat Lung | 1 |
| Eddie McGee | 1 | |
| Lou Martini Jr. | Coffee Truck Owner | 1 |
| Laverne Cox | God (voice) | 1 |
| Adrian Martinez | Darryl | 1 |
| James Ciccone | Jimbo the Dealer | 1 |
| Alan Kim | Young Wally | 1 |
| Bella Heathcote | Joey | 1 |
| Lauren Ash | Woman at Poolside | 1 |
| Frankie Muniz | Shawn | 1 |
| Judy Gold | The Librarian | 1 |
| Judy Gold | Connie Linguist | 1 |
| Clem Cheung | Wei | 1 |
| Jo Koy | Bob (voice) | 1 |
| Aaron Takahashi | Jacques | 1 |
| Noah Robbins | Jaxon | 1 |
| Jamar Greene | Casino Security Guard | 1 |
| Emma Hong | Rian | 1 |
| Natalie Carter | Woman | 1 |
| Venida Evans | Raspy Voiced Casino Woman | 1 |
| Manini Gupta | Dr. Shithra | 1 |
| Robert G. McKay | Doctor | 1 |
| Jordan Carlos | Xavier | 1 |
| Matt Rogers | Justin Schultz-Boudreaux | 1 |
| Catherine Curtin | Dude Ranch Debbie | 1 |
| Carmine Famiglietti | Gino | 1 |
| Alex Wong | Red Guard | 1 |
| David Fierro | Guy | 1 |
| Erika Bowman | Receptionist | 1 |
| Annie Pisapia | Lesbian Biker | 1 |
| Fay Ann Lee | Kim | 1 |
| Buzz Roddy | 1 | |
| Barbara Andres | Greta's Nanny | 1 |
| Chase Fein | Nick | 1 |
| Carmen M. Herlihy | Ling | 1 |
| Wesley Han | Joshua | 1 |
| Makeda Declet | Chenise | 1 |
| Robert Lee Leng | Marcus | 1 |
| Catherine Cohen | Jennifar | 1 |
| Melissa Villaseñor | 1 | |
| Deidre Goodwin | Detective Dornetto | 1 |
| Peter Van Wagner | Ted the Banker | 1 |
| Jade Wu | Cousin Rosalind | 1 |