| Name | Character | Episodes |
|---|---|---|
| David Thewlis | Lawrence Hatfield | 10 |
| Nina Toussaint-White | Kate Hatfield | 10 |
| Michelle Fairley | Meredith Hatfield | 10 |
| Guy Burnet | Tom Hatfield | 10 |
| Jing Lusi | Miyu Hatfield | 10 |
| Clare-Hope Ashitey | Evelyn Kern | 10 |
| Shaquille Ali-Yebuah | Danny | 10 |
| Jeremy Neumark Jones | Ben Hatfield | 10 |
| Anneika Rose | Natalie | 7 |
| Pete MacHale | Leon | 7 |
| Ursula Holliday | Cass | 7 |
| Anson Boon | Anton Garin | 5 |
| T'Nia Miller | Charlie Morris | 4 |
| Olwen Fouéré | Jane | 4 |
| Sheila Atim | Amanda Javad | 4 |
| Laurie Kynaston | Jonah Green | 4 |
| Art Malik | President Quan | 3 |
| Carlyss Peer | Martha | 3 |
| Anna Koval | Gwen Ashe | 3 |
| Clive Russell | Graham | 2 |
| Aoife Hinds | Lyla | 2 |
| Jonathan Aris | Eric Bell | 2 |
| Michael Wildman | ICSA Agent Ryan | 2 |
| Steven Elder | Doctor (Asylum) | 2 |
| Ace Bhatti | Dr. Adu | 2 |
| Finbar Lynch | Aidan Doyle | 1 |
| Tanya Moodie | Sue Cole | 1 |
| Sandra Teles | Female Reporter | 1 |
| Ravin J. Ganatra | News Reporter | 1 |
| Michael Higgs | Alec | 1 |
| Luca Matteo Zizzari | Italian Man | 1 |
| Muzz Khan | Coder | 1 |
| Oaklee Pendergast | Ryan | 1 |
| Alexander Hanson | James Parslow | 1 |
| Milo Twomey | Scientist | 1 |
| Carlyss Peer | Martha Freeman | 1 |
| Dai Tabuchi | Chef | 1 |
| Micah Balfour | ICSA Agent | 1 |
| Robert Goodman | Johnny | 1 |
| Claudia Jolly | Nurse (Dr Adu) | 1 |
| Nigel Boyle | Gary | 1 |
| Jodie Tyack | Laura | 1 |
| Claire Rafferty | Claire Leabridge | 1 |
| Rayna Campbell | ICSA Agent 2 | 1 |
| Eloise Joseph | Chetna | 1 |
| Mark Burgess | Mr. Barker | 1 |
| Neran Persaud | Head of Indian Feed | 1 |
| Mark Ebulue | ICSA Officer | 1 |
| Rez Kempton | Patrick Francis | 1 |