| The world's leading deception researcher, Dr. Cal Lightman, studies facial expression, body language and tone of voice to determine when a person is lying and why, which helps law enforcement and government agencies uncover the truth. But his skills also make it easier for him to deceive others. |
| Name | Character | Episodes |
|---|---|---|
| Tim Roth | Cal Lightman | 48 |
| Kelli Williams | Gillian Foster | 48 |
| Monica Raymund | Ria Torres | 48 |
| Brendan Hines | Eli Loker | 48 |
| Hayley McFarland | Emily Lightman | 40 |
| Mekhi Phifer | Ben Reynolds | 24 |
| Kristen Ariza | Heidi | 10 |
| Jennifer Beals | Zoe Landau | 6 |
| Tim Guinee | Alec Foster | 4 |
| Erika Christensen | 3 | |
| Sean Patrick Thomas | Karl Dupree | 3 |
| Brandon W. Jones | Liam | 3 |
| Michael B. Jordan | Key | 2 |
| Manny Montana | Dax | 1 |
| Jonathan Banks | Bitcher | 1 |
| Dean Norris | Dawkins | 1 |
| D.B. Woodside | Henry Strong | 1 |
| Mahershala Ali | Detective Hughes | 1 |
| David Harbour | Frank Ambrose | 1 |
| Shea Whigham | Jered Blunt | 1 |
| Tricia Helfer | Naomi Russell | 1 |
| Alona Tal | 1 | |
| Katherine LaNasa | Laura Cross | 1 |
| Amanda Schull | Phoebe | 1 |
| Alicia Coppola | Sheila Redatti | 1 |
| Mary Mouser | Tyler Seeger | 1 |
| Jason Gedrick | 1 | |
| Sasha Roiz | Captain David Markov | 1 |
| Kevin Tighe | Fletcher Bellwood | 1 |
| Jason Beghe | Captain Hoopes | 1 |
| Max Martini | Dave Burns | 1 |
| Rick Hoffman | Peters | 1 |
| Danai Gurira | Michelle Russo | 1 |
| Marc Blucas | 1 | |
| Megan Follows | Lorraine Burch | 1 |
| Omari Hardwick | 1 | |
| Currie Graham | Eric Kuransky | 1 |
| Patrick Fischler | Olson | 1 |
| Kosha Patel | Kiran Purohit | 1 |
| Ajay Mehta | Rohit | 1 |
| Alison La Placa | Diane Ktretschmer | 1 |
| Anthony Ruivivar | FBI Agent Dardis | 1 |
| Fredric Lehne | Kevin Warren | 1 |
| Alicia Lagano | Sheila Lake | 1 |
| John Carroll Lynch | Mr. Reed | 1 |
| Johanna Braddy | Jacquelin Mathis | 1 |
| April Grace | 1 | |
| Molly Price | Deputy Director Messler | 1 |
| Madeline Carroll | Samantha | 1 |
| James Frain | 1 | |
| Abby Brammell | 1 | |
| Megan Dodds | Gail | 1 |
| Antonio Fargas | Mr. Mitchell | 1 |
| Daniel Sunjata | Andrew Jenkins | 1 |
| Patrick J. Adams | 1 | |
| Doug Hutchison | Wayne | 1 |
| José Zúñiga | 1 | |
| Emilio Rivera | Tony Calvo | 1 |
| Virginia Williams | Nadia Dawson | 1 |
| Pej Vahdat | Jason Kashani | 1 |
| Anthony Azizi | Omar Kahn | 1 |
| Matt Gerald | Marshal Johnson | 1 |
| Kenneth Mitchell | Duane Corey | 1 |
| Deirdre Lovejoy | Holly Sando | 1 |
| Josh Stamberg | A.U.S.A. Hutchinson | 1 |
| Diane Baker | Judge Quinn | 1 |
| Pasha D. Lychnikoff | 1 | |
| Sarah Ramos | Riley Berenson | 1 |
| Michael B. Silver | Personick's Attorney | 1 |
| Shawn Doyle | Mike Salinger | 1 |
| Dale Midkiff | 1 | |
| Charles Parnell | Major Harris | 1 |
| Van Epperson | Polygrapher | 1 |
| Todd Stashwick | 1 | |
| Haley Ramm | Amy | 1 |
| Meta Golding | 1 | |
| Jay R. Ferguson | 1 | |
| Nolan Gerard Funk | Dan | 1 |
| James Marsters | 1 | |
| Spencer Garrett | 1 | |
| Timothy Carhart | 1 | |
| Matt Malloy | NASA Director Schaumburg | 1 |
| Stacy Edwards | Dr. Knowlton | 1 |
| Michelle Joyner | Marlene | 1 |
| Mark Rolston | 1 | |
| Sam Ball | Joe Spaly | 1 |
| Sunkrish Bala | Arun Ashraf | 1 |
| Bobby Soto | Louis | 1 |
| Troy Winbush | Wallace | 1 |
| Jon Sklaroff | Larry | 1 |
| Brian Tee | Bodyguard (Han Yong-Dae) | 1 |
| David Anders | Sgt. Scott | 1 |
| Nick Searcy | Mr. Donnelly | 1 |
| Anthony Starke | 1 | |
| Scott Paulin | Gerald Cooke | 1 |
| Keston John | Moon | 1 |
| Angela Bullock | Nurse | 1 |
| Kirk B.R. Woller | Mike Personick | 1 |
| Daniel Benzali | Joseph Hollin | 1 |
| Andrew Rothenberg | Kevin Rich | 1 |
| Jackie Debatin | Cheyenne | 1 |
| Dan Martin | Conrad Ricks | 1 |
| Tom Verica | Paul Aronson | 1 |
| Tiffany Hines | Lacey | 1 |
| Michael A. Goorjian | 1 | |
| Allie Gonino | Susan | 1 |
| Scott Klace | Martin Wexler | 1 |
| Mireille Enos | Cheryl Ambrose | 1 |
| Clea DuVall | Michelle Russell | 1 |
| Theo Rossi | Tressler | 1 |
| Lennie James | 1 | |
| Garret Dillahunt | 1 | |
| D.W. Moffett | Dr. Jeffrey Buchanan | 1 |
| Jake Thomas | James Cooke | 1 |
| Mageina Tovah | Natalie | 1 |
| Bruce Weitz | Leo O'Sullivan | 1 |
| Carmen Argenziano | Gus | 1 |
| Sean O'Bryan | 1 | |
| Jim Meskimen | 1 | |
| John Pyper-Ferguson | 1 | |
| Matt Bushell | David Caddick | 1 |
| Brian Howe | Garrett Denning | 1 |
| Rance Howard | Joe Metz | 1 |
| Mandy June Turpin | Carolyn Hollin | 1 |
| Jonno Roberts | Milo | 1 |
| Natalie Dreyfuss | Molly | 1 |
| Kathryn Meisle | Mary Cooke | 1 |
| Michael Raymond-James | 1 | |
| Christine Adams | Farida Mugisha | 1 |
| Michael Patrick McGill | 1 | |
| Andy Umberger | Peters | 1 |
| Marc Vann | Jim Gunderson | 1 |
| Richmond Arquette | 1 | |
| Rebecca Field | 1 | |
| Steven Flynn | Keith Berenson | 1 |
| Mary Mara | Krentz | 1 |
| Tim Griffin | Principle Castle | 1 |
| Mekenna Melvin | Stefanie Fife | 1 |
| Charles Rahi Chun | Korean Man | 1 |
| Cheryl White | Mayor Meredith Fallon | 1 |
| James MacDonald | Detective Riley | 1 |
| Kelvin Han Yee | Ambassador Park Jung-Soo | 1 |
| Carlos Lacámara | Inspector Mike Adams | 1 |
| Shashawnee Hall | Larry Bernardo | 1 |
| Richard Brooks | City Engineer Boulware | 1 |
| John Aprea | Victor Musso | 1 |
| Jose Pablo Cantillo | 1 | |
| Bernard White | Imam Amir Hadad | 1 |
| Brad Beyer | Lieutentant Tom Clayton | 1 |
| Robert Wisdom | Bonds | 1 |
| Allen Maldonado | Caden | 1 |
| Kurt Caceres | Jack Garcia | 1 |
| Michael Bofshever | Gov. Matt Goldin | 1 |
| Scott Alan Smith | Jeremy Levine | 1 |
| Gretchen Egolf | 1 | |
| Michele Nordin | Melissa | 1 |
| Brett Rice | Chief Jack Morrow | 1 |
| Ross Thomas | Doug Donovan | 1 |
| Anne Bedian | Hasina Kahn | 1 |
| Rick Fitts | Male Protestor | 1 |
| Kari Coleman | Mrs. McLaughlin | 1 |
| Randy Oglesby | Congressman Weil | 1 |
| Bradford Tatum | Peter Burch | 1 |
| Amy Rosoff | Private Metz | 1 |
| Chris McGarry | FEMA Commander Stevens | 1 |
| Lauren Bowles | Valerie Blunt | 1 |
| Stacey Moseley | ICU Nurse | 1 |
| Scott Atkinson | Howard Taft | 1 |
| Christie Burson | Kerry Morrow | 1 |
| Vince Corazza | Deputy Whitmore | 1 |
| Kevin McCorkle | 1 | |
| JD Cullum | Dr. Dembeck | 1 |
| J. Downing | Mr. Roland | 1 |
| Patrick Cavanaugh | Groomsman #2 | 1 |
| Don Wallace | Sharif Hamza Ali | 1 |
| Arlene Tur | Kimi | 1 |
| Colton Shires | Zack | 1 |
| Matt Corboy | 1 | |
| Jim Hanna | Ken | 1 |
| Anjul Nigam | Shreyas Patel | 1 |
| David Warshofsky | Owen Finnegan | 1 |
| Harold 'House' Moore | Little Sid | 1 |
| Adam Crosby | Troy Dixon | 1 |
| Nicole DuPort | 1 | |
| Jim Holmes | Skinhead's Attorney | 1 |