| The two Warner Brothers Yakko and Wakko and their Warner sister Dot had been (supposedly) created in the 1930's, but their cartoons were too screwy for the general public to handle. The three Warners were locked up in the studio water tower until they escaped in the 90's. There, they run wild, causing chaos everywhere! |
| Name | Character | Episodes |
|---|---|---|
| Sherri Stoner | Slappy Squirrel (voice) | 275 |
| Chick Vennera | Pesto (voice) | 275 |
| Tress MacNeille | Dot (voice) | 275 |
| Rob Paulsen | Yakko / Pinky (voice) | 275 |
| Nancy Cartwright | Mindy (voice) | 275 |
| Maurice LaMarche | The Brain / Squit (voice) | 275 |
| Jess Harnell | Wakko (voice) | 275 |
| John Mariano | Bobby (voice) | 275 |
| Frank Welker | Runt / Buttons (voice) | 172 |
| Bernadette Peters | Rita (voice) | 172 |
| Paul Rugg | Mr. Director (voice) | 4 |
| Mary Gross | Katie's Mom (voice) | 3 |
| Jim Cummings | Narrator (voice) | 2 |
| Maurice LaMarche | Self - Host | 2 |
| Cree Summer | Elmyra Duff (voice) | 2 |
| Julie Brown | Minerva Mink (voice) | 2 |
| Ron Perlman | Satan (voice) | 1 |
| Michael McKean | Spink (voice) | 1 |
| John Rhys-Davies | Tympannini (voice) | 1 |
| Jeff Bennett | Captain Mel (voice) | 1 |
| Jeff Bennett | Charlton "Baynarts" Woodchuck (voice) | 1 |
| Dan Castellaneta | Dracula (voice) | 1 |
| Kath Soucie | Fifi LaFume (voice) | 1 |
| Phil Hartman | Dan Anchorman (voice) | 1 |
| Peter Hastings | Writer (voice) | 1 |
| Kenneth Mars | Beethoven (voice) | 1 |
| Richard Libertini | Wally Llama (voice) | 1 |
| Jonathan Winters | Stinkbomb D. Basset (voice) | 1 |
| Christopher Guest | Umlatt (voice) | 1 |
| Andrea Romano | Director (voice) | 1 |
| Peter Scolari | Wilford Wolf (voice) | 1 |
| Ben Stein | Pip Pumphandle (voice) | 1 |
| Paul Rugg | Einstein (voice) | 1 |
| Paul Rugg | Mr. Clown (voice) | 1 |
| Paul Rugg | Freakazoid (voice) | 1 |
| Dave Thomas | King Arthur (voice) | 1 |
| Julia Kato | Miss Tanaka (voice) | 1 |
| Tom Ruegger | Producer (voice) | 1 |