Popularity: 4
| Creator: | Chuck Lorre | 
|---|
| Name | Character | Episodes | 
|---|---|---|
| Michael Douglas | Sandy Kominsky | 22 | 
| Nancy Travis | Lisa | 22 | 
| Sarah Baker | Mindy Kominsky | 22 | 
| Alan Arkin | Norman Newlander | 16 | 
| Graham Rogers | Jude | 14 | 
| Casey Thomas Brown | Lane | 14 | 
| Jenna Lyng Adams | Darshani | 14 | 
| Emily Osment | Theresa | 10 | 
| Ashleigh LaThrop | Breana | 10 | 
| Lisa Edelstein | Phoebe Newlander | 9 | 
| Susan Sullivan | Eileen Newlander | 8 | 
| Kathleen Turner | Roz | 7 | 
| Paul Reiser | Martin Schneider | 6 | 
| Jane Seymour | Madelyn | 5 | 
| Danny DeVito | Dr. Wexler | 2 | 
| Ann-Margret | Diane | 2 | 
| Adam Zastrow | Marcus | 2 | 
| Haley Joel Osment | Robbie Schumacher | 1 | 
| Bob Odenkirk | Dr. Eugene Shenckman | 1 | 
| Allison Janney | Self | 1 | 
| Elliott Gould | Himself | 1 | 
| Corbin Bernsen | Himself | 1 | 
| Lauren Weedman | Director | 1 | 
| Azie Tesfai | Lynda | 1 | 
| Jay Leno | Self | 1 | 
| Rex Linn | Ed | 1 | 
| George Wyner | Rabbi | 1 | 
| Jason Kravits | Woody Littlehales | 1 | 
| Becky O'Donohue | Car GPS (voices) | 1 | 
| Raymond Ma | Mr. Liu | 1 | 
| Ravi Kapoor | Dr. Bhonani | 1 | 
| Butch Klein | Buddy | 1 | 
| Elizabeth Sung | Mrs. Liu | 1 | 
| David James Elliott | William | 1 | 
| Lainie Kazan | Norman's Grandmother | 1 | 
| Annie Tedesco | Montana's Mother | 1 | 
| Jocelyn Towne | Jeanine | 1 | 
| Tommy Walker | Ted | 1 | 
| Aaron Schwartz | Walter | 1 | 
| Jeffrey D. Sams | Arthur Dickerson | 1 | 
| Jen Drohan | Rehab Receptionist | 1 | 
| Patti LaBelle | Self | 1 | 
| Delon de Metz | Andrew | 1 | 
| Rebekah Graf | Ricki | 1 | 
| Amanda Perez | Carol | 1 | 
| Kamilla Alnes | Dr. Shenckman's secretary | 1 | 
| Willam Belli | Cherry | 1 |