| Name | Character | Episodes |
|---|---|---|
| Nicola Walker | Hannah Sterne | 18 |
| Deborah Findlay | Ruth Defoe | 18 |
| Annabel Scholey | Nina Defoe | 18 |
| Stephen Mangan | Nathan Sterne | 18 |
| Fiona Button | Rose Defoe | 18 |
| Elizabeth Roberts | Liv Stern | 12 |
| Chukwudi Iwuji | Zander | 12 |
| Ellora Torchia | Maggie Lavelle | 12 |
| Barry Atsma | Christie | 12 |
| Rudi Dharmalingam | James | 12 |
| Damien Molony | Tyler Donaghue | 6 |
| Anthony Stewart Head | Oscar | 6 |
| Meera Syal | Goldie | 6 |
| Stephen Tompkinson | Davey | 6 |
| Amaka Okafor | Chloe | 6 |