| Name | Character | Episodes |
|---|---|---|
| Ciarán Hinds | Sir John Franklin | 10 |
| Ian Hart | Thomas Blanky | 10 |
| Tobias Menzies | Captain James Fitzjames | 10 |
| Jared Harris | Captain Francis Crozier | 10 |
| George Takei | Nobuhiro Yamato / Yamato-san | 10 |
| Adam Nagaitis | Cornelius Hickey | 10 |
| Matthew McNulty | LT. Edward Little | 10 |
| Cristina Rodlo | Luz Ojeda | 10 |
| Nive Nielsen | Lady Silence / Silna | 10 |
| Paul Ready | Doctor Henry Goodsir | 10 |
| Kiki Sukezane | Yuko Tanabe | 10 |
| Miki Ishikawa | Amy Yoshida | 10 |
| Naoko Mori | Asako Nakayama | 10 |
| Jack Colgrave Hirst | Thomas Hartnell | 10 |
| Hira Ambrosino | Fumi Yoshida | 8 |
| Lee Shorten | Walt Yoshida | 7 |
| C. Thomas Howell | Major Bowen | 5 |
| Greta Scacchi | Lady Jane Franklin | 4 |
| Christopher Naoki Lee | Ken Uehara | 4 |
| Sian Brooke | Sophie Cracroft | 4 |
| James Saito | Wilson Yoshida | 3 |
| Reed Diamond | Colonel Stallings | 3 |
| William MacDonald | George Nicol | 3 |
| Alma Martinez | Rocio Trujillo | 3 |
| Reilly Dolman | Marlon Harris | 2 |
| Rubén Garfias | Bart Ojeda | 2 |
| Marcus Toji | Arthur Ogawa | 2 |
| Raf Rogers | Julio | 1 |
| Sab Shimono | Kazu | 1 |
| Geoff Gustafson | MP | 1 |
| Teach Grant | Stan Grichuk | 1 |
| Matthew Finlan | MP Mosley | 1 |
| Sian Brooke | Sophia Cracroft | 1 |
| Chad Rook | Dale Skaggs | 1 |
| Peter Shinkoda | Sergeant Ishinabe | 1 |