| Name | Character | Episodes |
|---|---|---|
| Meghann Fahy | Sutton Brady | 52 |
| Aisha Dee | Kat Edison | 52 |
| Melora Hardin | Jacqueline Carlyle | 52 |
| Katie Stevens | Jane Sloan | 52 |
| Sam Page | Richard 'Dick' Mott | 48 |
| Matt Ward | Alex Crawford | 48 |
| Adam Capriolo | Andrew Morrison | 39 |
| Stephanie Costa | Sage Aiello | 31 |
| Dan Jeannotte | Ryan Decker | 28 |
| Nikohl Boosheri | Aden 'Adena' El Amin | 24 |
| Gildart Jackson | Ian Carlyle | 16 |
| Peter Vack | Patrick Duchand | 9 |
| Alexis Floyd | Tia Clayton | 8 |
| Mat Vairo | Scott Coleman | 7 |
| Christine L. Nguyen | Addison Harper | 7 |
| Alex Paxton-Beesley | Ava Rose | 6 |
| Aidan Devine | RJ Safford | 5 |
| Shyrley Rodriguez | Angela 'Angie' Flores | 5 |
| Yasha Jackson | Alicia Golden | 4 |
| Mark Ghanimé | Dev | 4 |
| Emily C. Chang | Lauren Park | 4 |
| Siobhan Murphy | Cleo Williams | 4 |
| Fiona Highet | Susan Edison | 4 |
| Rebecca Croll | Victoria Johnson | 4 |
| Rya Kihlstedt | Barbara 'Babs' Brady | 3 |
| Tom Austen | Cody | 3 |
| Katharine King So | Mitzi | 3 |
| Katerina Tannenbaum | Leila | 3 |
| Kelly AuCoin | Jane's Father | 3 |
| Tattiawna Jones | Jessica | 3 |
| Alexandra Turshen | Brooke Langley | 3 |
| Katelyn Wells | Daphne | 3 |
| Ellen David | Dr. Gerard | 3 |
| Auden Larratt | James Carlyle | 3 |
| Lyla Porter-Follows | Ingrid | 2 |
| Scott Cohen | Miles Shaw | 2 |
| Caroline Lagerfelt | Claire Hunter | 2 |
| Cindy Sampson | Nicole Keating | 2 |
| Elana Dunkelman | Cynthia Martin | 2 |
| Raven-Symoné | Alice Knight | 2 |
| Sara Alicia Garcia | Lisa (Podcast Engineer) | 2 |
| Nicola Correia Damude | Dana Jacobs | 2 |
| Peter Francis James | Bobby O'Neill | 2 |
| Curtiss Cook | Marcus Edison | 2 |
| Carolina Bartczak | Eden | 2 |
| Jason Diaz | Zach | 2 |
| Ralph Prosper | Man | 2 |
| Tamara Brown | Peggy Lillard | 2 |
| Jessica B. Hill | Yodi | 2 |
| Melissa Paulson | Quinn | 2 |
| Matthew Kabwe | Councilman Lawrence Reynolds | 2 |
| Stefan Keyes | Cole (NY14 Interviewer) | 2 |
| Nora Guerch | Coco | 2 |
| Milcania Diaz-Rojas | Monica | 2 |
| Chris Sandiford | Bryan Henderson | 1 |
| Kalinka Pétrie | Kim Baker | 1 |
| Sagine Sémajuste | Rachel | 1 |
| Dusan Dukic | Photographer | 1 |
| Paul Zinno | Caleb | 1 |
| Teneisha Collins | Claire | 1 |
| Kelly Kruger | Trish Paley | 1 |
| Kevin McGarry | Dillon Frank | 1 |
| Rachel Boyd | Chelsea | 1 |
| Elizabeth Ashley | Pam | 1 |
| Laila Robins | Pamela Dolan | 1 |
| Laila Robins | Pamela Dolan (uncredited) | 1 |
| Gabrielle Graham | Daniella | 1 |
| Jane Wheeler | Tina | 1 |
| Andrew Bushell | Kevin | 1 |
| Mylène Dinh-Robic | Christina Rose | 1 |
| Helena Marie | Michelle | 1 |
| Celeste Desjardins | Natalie | 1 |
| Ashley Platz | Ellie | 1 |
| Chord Overstreet | Evan | 1 |
| Hamza Haq | Trevor | 1 |
| Matt Holland | Principal | 1 |
| Amber Goldfarb | Morgyn Stanley | 1 |
| Erin Agostino | Heather | 1 |
| Olivia Luccardi | Gina | 1 |
| Amrit Kaur | Ginny | 1 |
| Michael Xavier | Landon | 1 |
| Elisa Moolecherry | The Sexologist | 1 |
| Margaret Cho | Margaret Cho | 1 |
| Marcel Jeannin | 1 | |
| Christopher Hayes | Hugo | 1 |
| Howard Rosenstein | Jeff Seltzer | 1 |
| Sarah Booth | Michelle | 1 |
| Ali Stroker | Olivia | 1 |
| Kelly Craig | Caitlyn | 1 |
| Alexander Nunez | Evan | 1 |
| Joseph Cannata | Gorgeous Man | 1 |
| Erin Daniels | Mindy | 1 |
| Moni Ogunsuyi | Model | 1 |
| Jess Salgueiro | Cassie | 1 |
| Connor McMahon | Hot Guy | 1 |
| Dan Beirne | Toby | 1 |
| Danny Blanco Hall | Dante Matson | 1 |
| Kwasi Songui | Roy | 1 |
| Ana Cruz Kayne | Mia Lawrence | 1 |
| James Millington | Charles Steiner | 1 |
| Alli Chung | Kristen | 1 |
| Carson Kressley | Carson Kressley | 1 |
| Felicia Shulman | Darlene | 1 |
| Katelyn Wells | Assistant Photographer | 1 |
| Linda E. Smith | Congresswoman | 1 |
| Sean Tucker | Larry | 1 |
| Vanessa Burns | Donna Baxter | 1 |
| Chantelle Han | Samantha | 1 |
| Patricia Summersett | Dr. Elysa Hendricks | 1 |
| Maria Herrera | Mrs. Diaz | 1 |
| Marcello Di Fruscia | Bartender | 1 |
| Kenny Wong | Sean Carpenter | 1 |
| Husein Madhavji | Jack | 1 |
| Ho Chow | Carl | 1 |
| Ellora Patnaik | Priya | 1 |
| Caitlyn Sponheimer | Allison Gabler | 1 |
| Arlen Aguayo-Stewart | Emily | 1 |
| Angela Galuppo | Emma | 1 |
| Cat Lemieux | Karen | 1 |
| Orphée Ladouceur-Nguyen | Clinic Receptionist | 1 |
| Myra Molloy | Mara Chamberlain | 1 |
| Samantha Cole | Frankie Williams | 1 |
| Kaitlyn Alexander | Cammy Hartman | 1 |
| Eddie Guillaume | Walt | 1 |
| Billie Jean King | Billie Jean King | 1 |
| Eric Davis | Josh Blagg | 1 |
| Holly Gauthier-Frankel | Female Voter | 1 |
| Natalie Liconti | Toni | 1 |
| Lydia Zadel | Christina Lippert | 1 |
| Olivier Ross-Parent | Bartender | 1 |
| Madeline Harvey | Bella's Lover | 1 |
| Jean Nicolai | Hospital Receptionist | 1 |
| Sabrina Campilii | Penny Davenport | 1 |
| Mary-Lu Zahalan | Linda Zephyr | 1 |
| Bobby Manning | Delivery Guy | 1 |
| Mekdes Teshome | Photographer | 1 |
| Kim Nelson | Press Secretary | 1 |
| Cameron Brodeur | James Carlyle | 1 |
| Letitia Brookes | Miriam | 1 |
| Suzanna Lenir | Audience Member #1 | 1 |
| Stefanie Nakamura | Young Woman #2 | 1 |
| Ivan Smith | Marshall | 1 |
| Sasha Velour | Sasha Velour | 1 |
| Shila Ommi | Shamsi | 1 |
| Dave Campbell | Security Guard #1 | 1 |
| Claudia Jurt | Audience Member #2 | 1 |
| Paulina Abarca-Cantin | Matronly Woman | 1 |