| Name | Character | Episodes |
|---|---|---|
| Amy Acker | Caitlin Strucker | 29 |
| Jamie Chung | Clarice Fong / Blink | 29 |
| Emma Dumont | Lorna Dane / Polaris | 29 |
| Percy Hynes White | Andy Strucker | 29 |
| Stephen Moyer | Reed Strucker | 29 |
| Natalie Alyn Lind | Lauren Strucker | 29 |
| Coby Bell | Jace Turner | 29 |
| Blair Redford | John Proudstar / Thunderbird | 29 |
| Skyler Samuels | Esme Frost / Sophie Frost / Phoebe Frost | 21 |
| Hayley Lovitt | Sage | 20 |
| Grace Byers | Reeva Payge | 16 |
| Jeff Daniel Phillips | Tex / Fade | 11 |
| Jermaine Rivers | Shatter | 10 |
| Elena Satine | Sonya Simonson / Dreamer | 9 |
| Garret Dillahunt | Dr. Roderick Campbell | 9 |
| Joe Nemmers | Agent Weeks | 9 |
| Frances Turner | Paula Turner | 7 |
| Renes Rivera | Bulk | 7 |
| Chelle Ramos | Heather | 6 |
| Tyshon Freeman | Tico | 6 |
| Peter Gallagher | Benedict Ryan | 5 |
| Anjelica Bette Fellini | Rebecca / Twist | 5 |
| Dinarte de Freitas | Pedro | 4 |
| Jessi Goei | Naya | 4 |
| Lowrey Brown | Kyle | 4 |
| Andrew Benator | Aide (Hound) | 4 |
| Laysla De Oliveira | Glow | 3 |
| Danny Ramirez | Wes | 3 |
| James Carpinello | Max | 3 |
| Elliott Grey | Director Wolcott | 3 |
| Carsten Nørgaard | Andreas Von Strucker | 3 |
| Vince Pisani | Dr. Kelsey | 3 |
| David Norona | Senator Matthew Montez | 3 |
| DJames Jones | Harry / Trader | 3 |
| Lily D. Moore | Shawna | 2 |
| Kate Burton | Dr. Madeline Risman | 2 |
| Zach Roerig | Pulse | 2 |
| Jeffrey Nordling | Danny | 2 |
| Raymond J. Barry | Otto Strucker | 2 |
| Anissa Matlock | Porcelain Mutant | 2 |
| Ray Campbell | William | 2 |
| William Mark McCullough | Michael | 2 |
| Sharon Gless | Ellen Strucker | 2 |
| Michael Aaron Milligan | Gravity Hound | 2 |
| Michelle Davidson | News Broadcaster #1 | 2 |
| Angela Oh | Chief of Staff | 2 |
| Gino Vento | Juan | 2 |
| Adam David Thompson | Graph | 2 |
| Mahdi Cocci | Security Guard | 2 |
| Ken Kirby | Noah | 2 |
| Christian Finlayson | Young Reed | 2 |
| Jordan Cox | Mason | 2 |
| Danube R. Hermosillo | Cristina | 2 |
| Olivia Grace Applegate | Pam | 1 |
| Bianca Berry Tarantino | Dawn | 1 |
| Toks Olagundoye | Carla Jackson | 1 |
| Mimi Fletcher | Nurse | 1 |
| Mark Rowe | Facility Owner | 1 |
| Mark Rowe | David Hine | 1 |
| Chase Anderson | Purifier #1 | 1 |
| Chase Anderson | Young Purifier | 1 |
| Jason Davis | Mr. Hoover | 1 |
| Sharif Atkins | Quinn | 1 |
| Robert C. Treveiler | Dan | 1 |
| Bob Jennings | Lodo | 1 |
| Kamar de los Reyes | Sebastian Diaz | 1 |
| Kurt Yue | Trask Employee | 1 |
| Alicia Kelley | Human Woman | 1 |
| Christopher Cousins | Lawrence Hayes | 1 |
| Agam Darshi | Benazir | 1 |
| Darren Goldstein | Chuck | 1 |
| Brad Carter | Wire | 1 |
| Chris Butler | Dr. Watkins | 1 |
| Susanna Skaggs | Young Polaris | 1 |
| Sumalee Montano | Dr. Taylor | 1 |
| Scarlett Blum | Dominique | 1 |
| Margo Moorer | OBGYN | 1 |
| Rose Bianco | Nun | 1 |
| Fin Argus | Jack | 1 |
| Leah Lewis | Young Clarice | 1 |
| Kathryn Erbe | Aunt Dane | 1 |
| Dale Godboldo | Ted Baird | 1 |
| Folake Olowofoyeku | Scar | 1 |
| Adam Boyer | Trask Security Guard | 1 |
| Erin Way | Shelia | 1 |
| David E. Collier | S.S. Agent | 1 |
| Courtney Dietz | Angry Mutant Girl | 1 |
| Stephan Jones | Driver | 1 |
| Cooper Roth | Scott | 1 |
| Brooke Jaye Taylor | SS Tactical Commander | 1 |
| Jim Dougherty | Pastor | 1 |
| John Crow | Reporter #2 | 1 |
| Diesel Madkins | Sentinel Service Officer | 1 |
| Billy Blair | Trucker Driver | 1 |
| Elizabeth Davidovich | Tough Woman #1 | 1 |
| Matthew Cornwell | Hound Tech | 1 |
| Robert G. McKay | Sergeant Lopez | 1 |
| Andrew Masset | Franklin Bennett | 1 |
| Steve Alderfer | SS Agent | 1 |
| Vishesh Chachra | Agent Novak | 1 |
| Clark Sarullo | Waitress | 1 |
| Jacinte Blankenship | Mutant Mom | 1 |
| Justin Matthew Smith | Thomas | 1 |
| Steven Sean Garland | Bank Manager | 1 |
| David Shae | Molecule Hound | 1 |
| Dave Blamy | Father | 1 |
| Marco Schittone | Young Boy | 1 |
| Ethan McDowell | Young Otto | 1 |
| Caitlin Mehner | Andrea von Strucker | 1 |
| Given Sharp | Lilly | 1 |
| Gunnar Anderson | Ryan's Assistant | 1 |
| Devin McGee | Mutant Prisoner | 1 |
| Tess Malis Kincaid | Campaign Manager | 1 |
| Dani Deetté | Sentinel Services Guard | 1 |
| Aerli Austen | Amber | 1 |
| Aaron Beelner | Small Mutant | 1 |
| Katelyn Farrugia | Nurse | 1 |
| Spence Maughon | Hospital Administrator | 1 |
| Omer Mughal | Crying SS Agent #1 | 1 |
| Tony DeMil | Guard #2 | 1 |
| Lloyd Pitts | SS Stunt Agent #2 | 1 |
| Christopher C. Padilla | Purifier #1 | 1 |
| Robert Bryan Davis | Purifier | 1 |
| Demi Castro | Father | 1 |
| Julia Farino | Andrea Von Strucker | 1 |
| Chase Steven Anderson | Ray | 1 |
| Christine Dunford | DOJ Official | 1 |
| Curtis Lyons | Strong Morlock | 1 |
| Fedor Steer | Membrain | 1 |
| Tom Glynn | SS Guard #2 | 1 |
| Tanya Wheelock | Bar Patron (uncredited) | 1 |
| Dayna Beilenson | Pedestrian #1 | 1 |
| Josué Gutierrez | Francisco | 1 |
| Alex Collins | Jack Campbell | 1 |