| Name | Character | Episodes |
|---|---|---|
| Jamie Glover | James Lacey | 25 |
| Jason Barnett | DCI Wilkes / DI Wilkes | 25 |
| Mathew Horne | Roy Silver | 25 |
| Ashley Jensen | Agatha Raisin | 25 |
| Lucy Liemann | Sarah Bloxby | 25 |
| Matt McCooey | DC Bill Wong / DS Bill Wong | 25 |
| Katy Wix | Gemma Simpson | 11 |
| Marcia Warren | Mrs. Boggle | 7 |
| Jodie Tyack | Toni Gilmour | 7 |
| Rhashan Stone | Jez Bloxby | 4 |
| Daisy Beaumont | Mary Fortune | 4 |
| Richard Durden | Mr. Boggle | 3 |
| Paul Bullion | Rob Friendly | 2 |
| James Lance | Jonny Shawpart | 2 |
| Caroline Langrishe | Sheila Barr | 2 |
| Peter Basham | Mick | 2 |
| Elizabeth Carling | Maggie Henderson | 2 |
| Andrea Lowe | Eve Pembery | 2 |
| Asan N'Jie | Gaz Towler | 2 |
| Caroline Loncq | Deirdra Darry | 2 |
| Robert Bathurst | Andy Cummings-Browne | 1 |
| Elarica Johnson | Lucy Trumpington-James | 1 |
| Annette Badland | Betty Jackson | 1 |
| Sally Bretton | Amanda Barton | 1 |
| Patsy Kensit | Emma Comfrey | 1 |
| Daniel Ings | Paul Bladen | 1 |
| Maimie McCoy | Rosie Wilden | 1 |
| Ron Donachie | Ron Allen | 1 |
| Emily Joyce | Juliet Comfort | 1 |
| Clare Holman | Robin Barley | 1 |
| Kelly Adams | Melissa Sheppard | 1 |
| Hermione Norris | Jo Cummings-Browne | 1 |
| Michael Byrne | Bishop Parsons | 1 |
| Joanna David | Lady Derrington | 1 |
| Stephen Boxer | Bernie Spott | 1 |
| Steven Brand | Inspector Jessop | 1 |
| Phoebe Thomas | Amy Redfern | 1 |
| Nancy Carroll | Fiona Richards | 1 |
| Amybeth McNulty | Young Agatha | 1 |
| James Dreyfus | Harry Witherspoon | 1 |
| Adam Garcia | George Felliet | 1 |
| Joseph Long | Spiros Economides | 1 |
| Sarah Flind | Mabel Dulsey | 1 |
| Kacey Ainsworth | Francie Juddle | 1 |
| John Hopkins | Tom 'Bunchie' Richards | 1 |
| Tom York | Zac Leeson | 1 |
| Rosalind Halstead | Cecilia | 1 |
| Terrence Hardiman | Mr. Green | 1 |
| Lara Rossi | Kristy King | 1 |
| Michael Cochrane | Sir Desmond | 1 |
| Jason Thorpe | Jimmy Raisin | 1 |
| Tommy Bastow | Barry Jackson | 1 |
| Kobna Holdbrook-Smith | Rev. Jez Bloxby | 1 |
| Anna Wilson-Jones | Tiggy Laggat-Brown | 1 |
| Abubakar Salim | Jonah McGillivray | 1 |
| Jacqueline Tong | Robina Toynbee | 1 |
| Roger Barclay | Major Nigel Findlay | 1 |
| Richenda Carey | Olivia Witherspoon | 1 |
| Richard Glover | John Dewey | 1 |
| Rosie Day | Karen Sheppard | 1 |
| Douglas Reith | Lord Pendlebury | 1 |
| John Lightbody | John Cartwright | 1 |
| Sagar Arya | Dr. Adder | 1 |
| Georgia Taylor | Steph | 1 |
| Amber Agar | Daisy Jones | 1 |
| Milo Twomey | Paul Redfern | 1 |
| Nell Hudson | Kylie Stokes | 1 |
| Joe Sims | Barry Briar | 1 |
| Don Gallagher | Coroner | 1 |
| Emma Stansfield | Alice Dewhurst | 1 |
| Richard Mylan | Jack The Lad Pomfret | 1 |
| Timothy Renouf | Danny Shine | 1 |
| Mark Arden | Terry Leeson | 1 |
| David Newman | Percy Fleming | 1 |
| Elisabeth Hopper | Julia Owens | 1 |
| Lu Corfield | Janine Juddle | 1 |
| Antonia Clarke | Beth Fortune | 1 |
| Robert Daws | Major Ted Huxby | 1 |
| Simon Meacock | Jason Briggs | 1 |
| Robin McCallum | Gustav | 1 |
| Rebecca Night | Deborah Camden | 1 |
| Martyn Ellis | Bernie Barrington | 1 |
| Richard Braine | Canon Gibbons | 1 |
| Dritan Kastrati | Cezary Marciniak | 1 |
| Mark Aiken | Florian Devere | 1 |
| Toby Williams | Postman | 1 |
| Oliver Lansley | Dr. Brendon Monk | 1 |
| Ruby Thomas | Portia Salmond | 1 |
| Sasha Frost | Berenice Chilton | 1 |
| Peter de Jersey | Claude Martin | 1 |
| Calvin A. Dean | Andy Buckley | 1 |
| Claire Cox | Carol Witherspoon | 1 |
| Debbie Chazen | Jessica Tarnick | 1 |