| Name | Character | Episodes |
|---|---|---|
| James Purefoy | John Waller | 4 |
| Laurence Fishburne | Alex Haley | 4 |
| Matthew Goode | Dr. William Waller | 4 |
| Jonathan Rhys Meyers | Tom Lea | 4 |
| Forest Whitaker | Fiddler | 4 |
| Anna Paquin | Nancy Holt | 4 |
| T.I. | Cyrus | 4 |
| Mekhi Phifer | Jerusalem | 4 |
| Anika Noni Rose | Kizzy | 4 |
| Malachi Kirby | Kunta Kinte | 4 |
| Genevieve Hannelius | Missy | 4 |
| Emayatzy Corinealdi | Belle | 4 |
| Regé-Jean Page | Chicken George | 2 |
| David Shiflett | Chicken Fight Gambler | 2 |
| Kelvin Harrison Jr. | Winslow | 1 |
| Emyri Crutchfield | Teen Miss Kizzy | 1 |
| Simona Brown | Jinna | 1 |
| Saniyya Sidney | Kizzy, age 6 | 1 |