| Name | Character | Episodes |
|---|---|---|
| Michael Degen | Dr. William Morton | 2 |
| Dieter Kirchlechner | Dr. Horace Wells | 2 |
| Peter Capell | Sir Thomas Barlow | 1 |
| Hans Elwenspoek | Sam Cooley | 1 |
| Sky du Mont | Prinz Albert | 1 |
| Franz Rudnick | Dr. Forrester | 1 |
| Gerd Baltus | Prof. William Stewart Halsted | 1 |
| Dieter Eppler | McBurns | 1 |
| Volker Brandt | Alexander Preschan | 1 |
| Robert Naegele | Tuchmann | 1 |
| Ursela Monn | Anja Bratko | 1 |
| Günter Meisner | Jackson | 1 |
| Karl Michael Vogler | Dr. Hartmann | 1 |
| Wolfgang Büttner | Sir Francis Laking | 1 |
| Wolfgang Kieling | Prof. Joseph Lister | 1 |
| Harald Leipnitz | Dr. Victor Horsley | 1 |
| Wolfgang Völz | Prof. Colton | 1 |
| Paul Hubschmid | Sir Frederick | 1 |
| Herbert Weißbach | Jeffries | 1 |
| Joachim Bißmeier | Dr. Ernst Fleischl | 1 |
| Reinhard Kolldehoff | Polizist Peiker | 1 |
| Rudolf Schündler | Schleich sr. | 1 |
| Gila von Weitershausen | Marthe | 1 |
| Klaus Münster | Reporter | 1 |
| Hans-Michael Rehberg | Captain Gilbey | 1 |
| Siegfried Wischnewski | Joseph Henderson | 1 |
| Nora Minor | Frau Fleischl | 1 |
| Lis Verhoeven | Esther Cabot | 1 |
| Carl Lange | Prof. Corney | 1 |
| Bernhard Wicki | König Edward VII. | 1 |
| Ida Krottendorf | Mrs. McBurns | 1 |
| Josef Fröhlich | Dr. Ignaz Semmelweis | 1 |
| Towje Kleiner | Giampiero Covalini | 1 |
| Gerd Vespermann | Arztkollege | 1 |
| Arnold Marquis | Dr. Robert Fitzpatrick | 1 |
| Arnold Marquis | Dr. Diefenbach | 1 |
| Walter Ladengast | Herr Fleischl | 1 |
| Günter Pfitzmann | Dr. Everett | 1 |
| Gerd Duwner | Herr Studienrat | 1 |