| The supernatural phenomenon begins again with a fresh crop of inspiring heroes who take on the ultimate struggle between those with extraordinary abilities and those with nefarious motives to hunt and harness their powers. Epic adventures await these newly empowered allies as they cross paths with some of the original characters, unlocking the mysterious fate of the universe and their place within it. |
| Name | Character | Episodes |
|---|---|---|
| Zachary Levi | Luke Collins | 13 |
| Rya Kihlstedt | Erica Kravid | 13 |
| Jack Coleman | Noah Bennet | 13 |
| Robbie Kay | Tommy Clarke | 13 |
| Danika Yarosh | Malina | 13 |
| Ryan Guzman | Carlos Gutierrez | 13 |
| Judi Shekoni | Joanne Collins | 13 |
| Kiki Sukezane | Miko Otomo | 13 |
| Henry Zebrowski | Quentin Frady | 13 |
| Krista Bridges | Anne Clark | 10 |
| Eve Harlow | Taylor Kravid | 9 |
| Clé Bennett | Harris Prime | 9 |
| Hiro Kanagawa | Hachiro Otomo | 8 |
| Nazneen Contractor | Farah Nazan | 8 |
| Lucius Hoyos | Jose Gutierrez | 8 |
| Pruitt Taylor Vince | Casper Abraham | 7 |
| Michael Therriault | Richard Schwenkman | 7 |
| Francesca Eastwood | Molly Walker | 5 |
| Greg Grunberg | Matt Parkman | 5 |
| Dylan Bruce | Captain James Dearing | 5 |
| Carlos Lacámara | Father Mauricio | 5 |
| Richie Lawrence | Dennis Collins | 5 |
| Nesta Cooper | Dahlia | 4 |
| Jake Manley | Brad | 4 |
| Noah Gray-Cabey | Micah | 4 |
| Peter Mooney | Francis | 3 |
| Masi Oka | Hiro Nakamura | 3 |
| Sendhil Ramamurthy | Dr. Mohinder Suresh | 3 |
| Cristine Rose | Angela Petrelli | 3 |
| Dean Armstrong | Special Agent Cole Cutler | 3 |
| Gregory Ambrose Calderone | Mick the Ice Guy | 3 |
| Raven Dauda | Deirdre | 3 |
| Marianne Farley | Julia | 3 |
| Marco Grazzini | Oscar Gutierrez | 2 |
| Tennille Read | Cheerful Renautas Woman | 2 |
| Eric Woolfe | Stevens | 2 |
| Rachael Ancheril | Fiona | 2 |
| Nneka Elliott | Janice Graves | 2 |
| Derwin Philips | Murphy | 2 |
| Sagine Sémajuste | Sylvia | 1 |
| Rachel Boyd | Injured Daughter | 1 |
| Joe Bostick | Phil | 1 |
| David Meunier | Scientist | 1 |
| David Meunier | Snyder | 1 |
| Stephanie Moore | Tomboy's Mom | 1 |
| Tamara Almeida | Paramedic | 1 |
| Simon Northwood | Sunstone Guard | 1 |
| Caitlin Carver | Young Erica | 1 |
| Sara Mitich | Lisa Carpenter | 1 |
| Jim Annan | Lab Tech | 1 |
| Romaine Waite | Detective | 1 |
| Nigel Shawn Williams | Dr. Don Mercer | 1 |
| Arnold Pinnock | 1 | |
| Trevor Hayes | Boat Salesman | 1 |
| Aron Tager | Old Angry Guy | 1 |
| Brendan Murray | Guard | 1 |
| Tammy Isbell | Dr. Lopez | 1 |
| Thomas Mitchell | Coach Lewis | 1 |
| Vanesa Tomasino | Spanish Reporter | 1 |
| Jas Dhanda | Parkman's Assistant | 1 |
| Sebastian MacLean | Security Guard | 1 |
| Adrian Griffin | Rumpled Detective | 1 |
| Christopher Cordell | Officer Pakowski | 1 |
| Lorna Wilson | Nurse | 1 |
| Elias Edraki | Pelon | 1 |
| Jordan Gray | Police Officer | 1 |
| Samantha Madely | Evacuee | 1 |
| Michael Murray | Charlie | 1 |
| Toby Proctor | Norris | 1 |
| Chantelle Chung | Smart Girl | 1 |
| Dan Warry-Smith | Young Casper Abraham | 1 |