| Name | Character | Episodes |
|---|---|---|
| Alona Tal | Rebecca King Vega | 13 |
| Hector Elizondo | 13 | |
| Polly Walker | Ellis Samuels | 13 |
| Nestor Carbonell | 13 | |
| Rita Moreno | Amalia Duque | 13 |
| Michael Trevino | Jaime Vega | 13 |
| Jimmy Smits | Alex Vega | 13 |
| Lina Esco | 13 | |
| Eddie Matos | 13 | |
| Ken Howard | 11 | |
| Jason Beghe | 7 | |
| Julio Oscar Mechoso | 6 | |
| Ned Vaughn | 6 | |
| John Pyper-Ferguson | 4 | |
| Rachael Carpani | 4 | |
| Paul Wesley | Nick | 3 |
| Todd Waring | 2 | |
| Blair Redford | 2 | |
| Brook Kerr | 2 | |
| Marsha Thomason | Miranda Sanfilipino | 1 |
| Gail O'Grady | 1 | |
| Nick Chinlund | 1 | |
| Alicia Keys | Self | 1 |
| Mimi Kennedy | 1 | |
| Michael B. Silver | 1 | |
| Nicole Scherzinger | 1 | |
| Jonathan Bennett | Brad | 1 |
| Lee Tergesen | 1 | |
| Joel Brooks | 1 | |
| Joyce Guy | 1 | |
| Christina Cole | 1 | |
| Christopher Cousins | 1 | |
| will.i.am | 1 | |
| Wolfgang Bodison | 1 | |
| Paul Carafotes | 1 | |
| Ray Santiago | 1 | |
| Allan Louis | 1 | |
| Rodney Eastman | 1 | |
| Chad Todhunter | 1 | |
| Kristin Cavallari | 1 | |
| Jonathon Trent | 1 | |
| Anya Monzikova | 1 | |
| Christina Chambers | 1 |