| Name | Character | Episodes |
|---|---|---|
| Christina Applegate | Jesse Warner | 42 |
| Eric Lloyd | Little John Warner | 42 |
| Liza Snyder | Linda | 42 |
| Bruno Campos | Diego Vasquez | 42 |
| George Dzundza | John Warner, Sr. | 22 |
| David DeLuise | Darren Warner | 22 |
| John Lehr | John Warner, Jr. | 22 |
| Darryl Theirse | Kurt Bemis | 21 |
| Kevin Rahm | Danny Kozak | 20 |
| Michael Weatherly | Roy | 6 |
| Jacqueline Obradors | Irma | 4 |
| Pauley Perrette | Gwen | 3 |
| Michael Welch | Gabe | 3 |
| Natasha Slayton | Tori | 3 |
| Thomas Lennon | Ernie | 2 |
| Fred Stoller | Delivery Man | 2 |
| Fred Stoller | Fred | 2 |
| Vince Vieluf | Patrick | 2 |
| Shia LaBeouf | Moe | 1 |
| Lesley Ann Warren | Susan | 1 |
| Grace Zabriskie | Granny Rose | 1 |
| Susie Park | Laura | 1 |
| Megan Ward | April | 1 |
| David Faustino | Dwayne | 1 |
| T.J. Thyne | Seth | 1 |
| Merrin Dungey | Rosemary | 1 |
| Charles Esten | Tad | 1 |
| Brian Posehn | Terry | 1 |
| Scott Thompson | Cecil | 1 |
| Hal Ozsan | Dawson | 1 |
| Scott Menville | Tommy O'Haver | 1 |
| Liz Torres | Rosa Vasquez | 1 |
| Susan Yeagley | Wedding Guest #3 | 1 |
| Susan Yeagley | Student | 1 |
| Reni Santoni | Pedro Vasquez | 1 |
| Chris Bruno | Rob | 1 |
| Joyce Guy | Teresa | 1 |
| Brande Roderick | Susan | 1 |
| Cheryl Ladd | Mary Anne Myers | 1 |
| Irene Olga López | Momma Vasquez | 1 |
| Christopher Darga | Sleezy Guy | 1 |
| Lisa Thornhill | Dana | 1 |
| Dan Gauthier | Jeff Hanson | 1 |
| Angela Paton | Mrs. Baum | 1 |
| Carlos Lacámara | Gate Attendant | 1 |
| Lorna Scott | DMV Worker | 1 |
| Brian Leckner | Big Guy | 1 |
| Regan Burns | Patient | 1 |
| Anil Raman | Student | 1 |
| John Mendoza | Fish Man | 1 |
| Pepe Serna | Pappa Vasquez | 1 |
| Michael Winters | INS Guy | 1 |
| Matt Landers | Security Guard | 1 |
| James Paradise | Guy at Piano Bar | 1 |
| Glenn Quinn | Sean | 1 |
| Paul Schackman | Delivery Guy | 1 |
| Joe Finfera | Lunch Hole Worker | 1 |
| Joe Finfera | Fireman | 1 |
| Jeff Brooks | Student | 1 |
| Tait Smith | Dump Guy | 1 |
| Philip Pavel | Terry | 1 |
| Peter Murrieta | Janitor | 1 |
| Marci Brickhouse | Marcy | 1 |
| Kate Asner | Mail Clerk | 1 |
| Kevin Berntson | Bar Patron #2 | 1 |
| Phil Buckman | Frank | 1 |
| Scott N. Stevens | Scott | 1 |
| Jim Bentley | Maitre D' | 1 |
| Lane Davies | Mr. Bergen | 1 |