| Name | Character | Episodes |
|---|---|---|
| Anjelica Huston | Eileen Rand | 32 |
| Debra Messing | Julia Houston | 32 |
| Jack Davenport | Derek Wills | 32 |
| Christian Borle | Tom Levitt | 32 |
| Katharine McPhee | Karen Cartwright | 32 |
| Megan Hilty | Ivy Lynn | 32 |
| Leslie Odom Jr. | Sam Strickland | 29 |
| Wesley Taylor | Bobby | 26 |
| Brian d'Arcy James | Frank Houston | 18 |
| Ann Harada | Linda | 18 |
| Jeremy Jordan | Jimmy Collins | 17 |
| Krysta Rodriguez | Ana Vargas | 17 |
| Michael Cristofer | Jerry Rand | 15 |
| Raza Jaffrey | Dev Sundaram | 15 |
| Emory Cohen | Leo Houston | 14 |
| Thorsten Kaye | Nick Felder | 13 |
| Will Chase | Michael Swift | 10 |
| Jesse L. Martin | Scott Nichols | 9 |
| Daphne Rubin-Vega | Agnes | 8 |
| Neal Bledsoe | John Goodwin | 7 |
| Daniel Abeles | Blake | 7 |
| Sean Dugan | Randall Jones | 6 |
| Bernadette Peters | Leigh Conroy | 6 |
| Uma Thurman | Rebecca Duvall | 5 |
| David Call | Adam | 5 |
| Phillipa Soo | Lexi | 5 |
| Montego Glover | Marissa | 5 |
| Daniel Sunjata | Peter Gilman | 4 |
| Dola Rashad | Cynthia Moran | 4 |
| Jamey Sheridan | Richard Francis | 4 |
| Charlie Semine | Paul Denby | 4 |
| Henry Stram | Justin | 4 |
| Jennifer Hudson | Veronica Moore | 3 |
| Dylan Baker | Roger Cartwright | 3 |
| Julian Ovenden | Simon | 3 |
| Jason Kravits | Timothy | 3 |
| Jennifer Ikeda | Lianne | 3 |
| Veanne Cox | Actress | 3 |
| Sean Hayes | Terry Falls | 3 |
| Natalie Paul | Actor #5 | 3 |
| Finnerty Steeves | Moira | 3 |
| Ching Valdes-Aran | Liz | 3 |
| Frankie J. Alvarez | Actor #6 | 3 |
| Luke Macfarlane | Patrick Dillon | 2 |
| Nick Jonas | Lyle West | 2 |
| Becky Ann Baker | Mrs. Cartwright | 2 |
| Maddie Corman | Rene Walters | 2 |
| Isiah Whitlock, Jr. | Ronald Strickland | 2 |
| Nikki Blonsky | Margo | 2 |
| Annaleigh Ashford | Lisa McMann | 2 |
| Hale Appleman | Zach | 2 |
| Rosie O'Donnell | Rosie O'Donnell | 2 |
| Grace Gummer | Katie Rand | 2 |
| Elain R. Graham | Vanessa Strickland | 2 |
| Eisa Davis | Abigail | 2 |
| Peter Rini | Petey | 2 |
| Lin-Manuel Miranda | Lin-Manuel Miranda | 1 |
| Lucy Walters | Suzanne | 1 |
| John Procaccino | Cooper | 1 |
| Cheyenne Jackson | Cheyenne Jackson | 1 |
| Samantha Soule | Donna | 1 |
| Margo Martindale | Miriam Abramson | 1 |
| Ron Rifkin | Ron Rifkin | 1 |
| Sheryl Lee Ralph | Cynthia Moore | 1 |
| Li Jun Li | Store Clerk | 1 |
| Christine Ebersole | Christine Ebersole | 1 |
| Julian Ovenden | John F. Kennedy | 1 |
| Geoffrey Cantor | Barry Schwartzman | 1 |
| Harvey Fierstein | Harvey Fierstein | 1 |
| Welker White | Betsy Fields | 1 |
| Andrea Bordeaux | Casting Assistant | 1 |
| Alice Lee | Bombshell Fan #1 | 1 |
| Jason Ralph | Fan | 1 |
| Kathie Lee Gifford | Kathie Lee Gifford | 1 |
| Alice Kremelberg | Actor #1 | 1 |
| Steve Park | Reporter #1 | 1 |
| Hinton Battle | Pastor | 1 |
| Marc Shaiman | Pianist | 1 |
| Marc Shaiman | Marc Shaiman | 1 |
| Happy Anderson | Doorman | 1 |
| Liza Minnelli | Liza Minnelli | 1 |
| Norbert Leo Butz | Norbert Leo Butz | 1 |
| Sophia Anne Caruso | Little Girl | 1 |
| Cole Escola | Coat Check Clerk | 1 |
| Edward Hibbert | Critical Previewer | 1 |
| David Fonteno | Deputy Mayor Klein | 1 |
| Mark Junek | Gary Knowles | 1 |
| Stephen Bogardus | Jeff Preston | 1 |
| James Monroe Iglehart | Assistant | 1 |
| Susan Blackwell | Stella Stewart | 1 |
| Teddy Cañez | Landlord | 1 |
| Frank De Julio | Patrick | 1 |
| Drew Gehling | Bartender | 1 |
| Jake Robinson | Drummer | 1 |
| Phil McGlaston | Lawyer | 1 |
| Erik Heger | Boyfriend | 1 |
| Nicole Orth-Pallavicini | Woman | 1 |
| Nitya Vidyasagar | Jill Abrams | 1 |
| Lindsay Mendez | Lindsay Mendez | 1 |
| Rebecca Naomi Jones | Laura | 1 |
| Dee Hoty | Director | 1 |
| Amina Robinson | Tia | 1 |
| Harrison Chad | August | 1 |
| Terrence Mann | Randy Cobra | 1 |
| Isis King | Waitress | 1 |
| Michael Musto | Michael Musto | 1 |
| Marc Kudisch | Darryl F. Zanuck | 1 |
| Ty Jones | Paul Strickland | 1 |
| Mary Testa | Hostess | 1 |
| Daniel Hartley | Ross | 1 |
| Oberon K.A. Adjepong | Town Car Driver | 1 |
| Brenda Braxton | Beautiful Mother | 1 |
| Sekou Laidlow | Production Assistant | 1 |
| Donna McKechnie | Female Previewer | 1 |
| Tom Kitt | Musician | 1 |
| Christine Toy Johnson | Dr. Holland | 1 |
| Anthony Arkin | Mr. Bishop | 1 |
| Ryan Tedder | Ryan Tedder | 1 |
| Marcus Schenkenberg | Colin | 1 |
| Steven Kaplan | Alan Rykoff | 1 |
| Lillias White | Lillias White | 1 |
| Robert LuPone | Jerry's Attorney | 1 |
| Kevin McCollum | Kevin McCollum | 1 |
| Armand Anthony | Commercial Director | 1 |
| Raymond J. Lee | Jon | 1 |
| Bernard Telsey | Bernard Telsey | 1 |
| Tanya Wheelock | Passerby (uncredited) | 1 |
| Kathleen Marshall | Kathleen Marshall | 1 |