| Name | Character | Episodes |
|---|---|---|
| Linda Cardellini | Sarah | 13 |
| Esteban Powell | Brian Holsapple | 13 |
| John Patrick White | Fitzgerald Crump | 8 |
| Charles Fleischer | Arnie | 7 |
| Dave Ruby | Buddy | 5 |
| Arthur Burghardt | Principal Pussman | 4 |
| Laraine Newman | Miss Dewberry | 2 |
| Erick Avari | Dr. Lumbago | 2 |
| Doug Jones | Mummy | 1 |
| Jim Beaver | Edgar Allan Poe | 1 |
| Stuart Pankin | Mr. Batrachian | 1 |
| Edie McClurg | Miss Webb | 1 |
| Elena Lyons | Julie Tchort | 1 |
| Paul Bartel | Mr. Tchort | 1 |
| Vincent Schiavelli | Dr. Hyde | 1 |
| Mary Woronov | Mrs. Tchort | 1 |
| Angus Scrimm | Hobo | 1 |
| Linda Pine | Evil Cheerleader (voice) | 1 |
| Carl V. Dupré | Zombie Twin | 1 |