| Name | Character | Episodes |
|---|---|---|
| Robert Hays | Iron Man (voice) | 26 |
| Dorian Harewood | War Machine (voice) | 26 |
| John Reilly | Hawkeye (voice) | 19 |
| Jim Cummings | M.O.D.O.K. (voice) | 16 |
| Chuck McCann | Blizzard (voice) | 15 |
| Katherine Moffat | Scarlet Witch (voice) | 13 |
| Jennifer Hale | Spider-Woman (voice) | 13 |
| Tony Steedman | Justin Hammer (voice) | 13 |
| James Warwick | Century (voice) | 13 |
| Ed Gilbert | The Mandarin (voice) | 13 |
| Robert Ito | The Mandarin (voice) | 13 |
| James Avery | War Machine (voice) | 13 |
| Tom Kane | H.O.M.E.R. | 13 |
| Neil Dickson | Dreadknight (voice) | 13 |
| Neil Ross | Fin Fang Foom (voice) | 6 |
| Philip Abbott | Nick Fury (voice) | 4 |
| Efrem Zimbalist Jr. | Justin Hammer (voice) | 3 |
| Jennifer Darling | Scarlet Witch (voice) | 3 |
| David Warner | Arthur Dearborn (voice) | 2 |
| William Morgan Sheppard | Dum Dum Dugan (voice) | 2 |
| Neil Ross | Anchorman (voice) | 2 |
| Neal McDonough | Firebrand (voice) | 1 |
| Ron Perlman | Hulk (voice) | 1 |
| Jim Cummings | Century (voice) | 1 |
| Peter Renaday | Walter Stark (voice) | 1 |
| Matt Frewer | Leader (voice) | 1 |
| Lisa Zane | Madame Masque (voice) | 1 |
| Sarah Douglas | Alana Ulanova (voice) | 1 |
| Todd Louiso | The Hacker (voice) | 1 |
| Jeannie Elias | Veronica Benning (voice) / Computer (voice) | 1 |
| William Hootkins | Crimson Dynamo (voice) | 1 |
| Scott Valentine | Dark Aegis (voice) | 1 |
| John Reilly | Jessik (voice) | 1 |
| Dimitra Arliss | Armor Computer Voice (voice) | 1 |
| Dimitra Arliss | Computer Voice (voice) | 1 |
| Julia Kato | Dr. Su-Yin (voice) | 1 |
| Ron Friedman | Record Producer (voice) | 1 |