| Name | Character | Episodes |
|---|---|---|
| Nicola Duffett | Cat MacKenzie | 1686 |
| Anna Acton | Geri Evans | 1179 |
| Rosie Rowell | 927 | |
| Tanya Franks | Karen Ellis | 918 |
| Chandra Ruegg | 918 | |
| Liz Crowther | Annie Hart | 695 |
| Tony Scannell | 695 | |
| Sandra Huggett | 695 | |
| Kate Williams | 690 | |
| Gareth Hale | Doug MacKenzie | 690 |
| Gary Webster | Gary Costello | 690 |
| Jan Harvey | 690 | |
| Kazia Pelka | Chrissy Costello | 690 |
| Julia-Lee Smith | 690 | |
| Kate O'Mara | 519 | |
| Gabrielle Glaister | Trish Wallace | 519 |
| Harry Capehorn | Bradley Foster | 519 |
| Beth Cordingly | Sara Warrington | 510 |
| Michael Wildman | Marc MacKenzie | 432 |
| Tony O'Callaghan | Mike Shaw | 432 |
| Florence Hoath | 258 | |
| John Hopkins | 258 | |
| Miles Anderson | George Shackleford | 256 |
| Anthony Booth | 254 | |
| Cyril Nri | 254 | |
| Valentine Pelka | 249 | |
| Cordelia Bugeja | 191 | |
| Shola Adewusi | Nurse | 1 |