| Name | Character | Episodes |
|---|---|---|
| Stevie Nicks | Self | 4 |
| Kris Kristofferson | Self | 2 |
| Josh Groban | 2 | |
| John Fogerty | 2 | |
| Martina McBride | 2 | |
| Michael McDonald | 2 | |
| Shelby Lynne | Self | 2 |
| Terrence Howard | Self | 1 |
| Billy Idol | 1 | |
| Idina Menzel | 1 | |
| Seal | 1 | |
| Mark Isham | Self | 1 |
| R.L. Stine | 1 | |
| Burt Bacharach | Self | 1 |
| Lisa Marie Presley | Self | 1 |
| Alan Jackson | 1 | |
| Travis Tritt | Self | 1 |
| Colin Hay | 1 | |
| Mark Knopfler | 1 | |
| Peter Frampton | 1 | |
| Kenny Chesney | 1 | |
| Buddy Guy | 1 | |
| Jackson Browne | 1 | |
| KT Tunstall | 1 | |
| Solange | Self | 1 |
| Richie Sambora | Self | 1 |
| Ronald Isley | Self | 1 |
| Trisha Yearwood | 1 | |
| Aaron Neville | 1 | |
| Steve Winwood | Self | 1 |
| Lucinda Williams | Self | 1 |
| Vince Gill | 1 | |
| Lindsey Buckingham | 1 | |
| David Foster | 1 | |
| Rickie Lee Jones | 1 | |
| B.B. King | Self | 1 |