| Name | Character | Episodes |
|---|---|---|
| Shelley Fabares | Jenny Bedford | 27 |
| Danny Thomas | Dr. Jules Bedford | 27 |
| Didi Conn | Helen | 27 |
| David Spielberg | Dr. David Bedford | 27 |
| Dena Dietrich | Molly Gibbons | 27 |
| John Byner | 2 | |
| James T. Callahan | 1 | |
| Victor Buono | 1 | |
| David Huddleston | 1 | |
| Vic Tayback | 1 | |
| Marlo Thomas | 1 | |
| Edie Adams | 1 | |
| Ivor Francis | 1 | |
| Marge Redmond | 1 | |
| Barry Gordon | 1 | |
| Lucille Ball | 1 | |
| Severn Darden | 1 | |
| Caren Kaye | 1 | |
| Jayne Meadows | 1 | |
| Art Metrano | 1 | |
| Ralph Manza | 1 | |
| Jan Murray | 1 | |
| William Cort | 1 |