| Name | Character | Episodes |
|---|---|---|
| Rob Morrow | Kevin Hunter | 33 |
| Michelle Nolden | Rachel Goldstein | 33 |
| Alexander Conti | Timmy Liberti | 21 |
| Scott Cohen | James Liberti | 20 |
| Christopher Bolton | Peter Hunter | 20 |
| Kate Greenhouse | Karen Liberti | 20 |
| Erika Alexander | Dee Mulhern | 20 |
| Simon Reynolds | Steve Goldstein | 15 |
| Allegra Fulton | Ann Valentine | 15 |
| Jack Knight | Sean Hunter | 14 |
| Terrence Howard | Lucius Mosley | 13 |
| Craig Eldridge | Chase MacPherson | 12 |
| Rod Wilson | Joe Ennis | 11 |
| Kathryn Zenna | Pia | 11 |
| Jeff Pustil | Gene the Bookie | 10 |
| Rob Smith | Ron Skouras | 8 |
| Gail Maurice | Skye Nighthawk | 6 |
| Don Francks | Don Goldstein | 6 |
| Danny Waugh | DEA Agent | 6 |
| Polly Shannon | Danielle | 5 |
| Juan Carlos Velis | Gusano Guzman | 5 |
| Richard Chevolleau | Adonis | 5 |
| Patricia Gage | Mary Hunter | 5 |
| Hector Elizondo | Fariz Hammoud | 4 |
| A.C. Peterson | Maurice Cohen | 4 |
| Red Buttons | Sam Kahan | 4 |
| Nazneen Contractor | Jasmine | 4 |
| Kenneth McGregor | Ty Nader | 4 |
| Keith Carradine | Frank Dugan | 3 |
| Kristen Holden-Ried | Dwayne | 3 |
| Lyriq Bent | Sergeant Danny Blackstone | 3 |
| Richard Zeppieri | Herbie Green | 3 |
| Patricia Zentilli | Bonnie Abrams | 3 |
| Philip Craig | Bob Hunter | 3 |
| Vito Rezza | Vinnie Palegra | 3 |
| Jacqueline Pillon | Linda Grady | 3 |
| Conrad Pla | Paco Aviles | 2 |
| Desmond Campbell | Black Con | 2 |
| Dash Mihok | Randy Wiggins | 2 |
| Billy Dee Williams | Charles White | 2 |
| Carlo Rota | Arthur Marx | 2 |
| Jonathan Potts | Paul Timmons | 2 |
| Ted Atherton | Larry Atwood | 2 |
| Boris Kodjoe | Bowman Calloway | 2 |
| Roman Podhora | Detective Giritlian | 2 |
| Nick Alachiotis | Latino Con | 2 |
| Jayne Heitmeyer | Vivian Beddoes | 2 |
| Jordan Prentice | 2 | |
| Awaovieyi Agie | Luther Steele / Brickman | 2 |
| Gale Harold | Geoff Beddoes | 2 |
| Shane Daly | Sylvester | 2 |
| Tommy Chang | Dojo Master | 2 |
| Amanda Smith | Screaming Passerby #1 | 2 |
| Joseph Pierre | Gangbanger #1 | 2 |
| Joan Heney | Sylvia Cahan | 2 |
| Giancarlo Esposito | Jesse Haslim | 1 |
| Daniel Dae Kim | Vo Nguyen | 1 |
| Dawne Furey | Brunette Biker Chick | 1 |
| Dawne Furey | Hooker #1 | 1 |
| Deborah Odell | Debbie Waxman | 1 |
| Ho Pak-Kwong | Grandfather | 1 |
| Brittany Allen | Connie | 1 |
| Serena Williams | Meeka Hayes | 1 |
| Rick Fox | Peter Samson | 1 |
| Martin Roach | Alfa Goodman | 1 |
| Paulino Nunes | Tommy Ray Benning | 1 |
| Kevin Rushton | Biker | 1 |
| Kevin Jubinville | L. Thompson Baines | 1 |
| Roman Podhora | Paul Bennett | 1 |
| Keith Knight | Randall King | 1 |
| Tony Nappo | Paul | 1 |
| Robert Forster | Tony DeAngelo | 1 |
| Swoosie Kurtz | Victoria Van Kleek | 1 |
| Raoul Bhaneja | Raj | 1 |
| Chris Owens | Assistant U.S. Attorney | 1 |
| Wendy Lyon | Mrs. Sloan | 1 |
| David Vadim | Burt Kent | 1 |
| Gordon Currie | Bob Morgan | 1 |
| Matt Birman | Dominic Liberti | 1 |
| Matt Birman | Priest | 1 |
| Judd Hirsch | Shimi Goldman | 1 |
| Lisa Marcos | Waitress | 1 |
| Lisa Marcos | Bar Maid | 1 |
| K.C. Collins | Rasheed | 1 |
| Maxwell McCabe-Lokos | The Cooker | 1 |
| Christopher Jacot | Phil Dorfman | 1 |
| Lynne Deragon | Mrs. Liberti | 1 |
| Conrad Coates | Philip Leeds | 1 |
| Michael Buie | Tobias | 1 |
| Michael Pavone | Donnie Paruana | 1 |
| Saul Williams | Greg Cooper | 1 |
| Philip Anthony-Rodriguez | Enrique Abascal | 1 |
| Joanne Baron | Beverly | 1 |
| Inga Cadranel | Carmen Aviles | 1 |
| Benz Antoine | Wallace Evans | 1 |
| Ted Whittall | Michael Kendry | 1 |
| Leah Renee | Marla | 1 |
| Milton Barnes | 1 | |
| Rothaford Gray | Guard | 1 |
| Neil Crone | Congressman Reemer | 1 |
| Sugith Varughese | Sujal | 1 |
| Roger Dunn | 1 | |
| Tig Fong | Hit Man | 1 |
| Scott Wickware | Detective | 1 |
| Scott Wickware | Corrections Officer | 1 |
| Eric Peterson | Monty | 1 |
| Kathleen Laskey | Sam's Daughter | 1 |
| Gary Reineke | Henry Wilkie | 1 |
| Bill Lake | Top Cop | 1 |
| Lorry Ayers | Travel Agent | 1 |
| Daniel Fathers | Jared Endelman | 1 |
| Gerry Salsberg | Herb Freeman | 1 |
| Stuart Hughes | George Phips | 1 |
| Michael Rhoades | Cop | 1 |
| Sandra P. Grant | White's Daughter | 1 |
| Kristin Adams | Carla | 1 |
| Jean Yoon | Dr. Whitsell | 1 |
| Alex Karzis | Felipe | 1 |
| Kira Clavell | Renata | 1 |
| Jamaal Grant | Bookstore Clerk | 1 |
| Ho Chow | Restaurant owner | 1 |
| Sarah Orenstein | Majera | 1 |
| Kathryn Winslow | Laura Conte | 1 |
| James Collins | Parolee | 1 |
| Frank Moore | William Sloan | 1 |
| Carlos Diaz | Tony Rodriguez | 1 |
| Jackie Richardson | Cleo | 1 |
| Victor Ertmanis | Lawyer | 1 |
| Steven McCarthy | 1 | |
| Eli Gabay | Ray Candella | 1 |
| Sandra Caldwell | Phyllis Cooper | 1 |
| Matthew MacFadzean | Luke Tilton | 1 |
| Diego Fuentes | Diablo | 1 |
| Valerie Buhagiar | Rabbi | 1 |
| Bruce Clayton | Bill Fowler | 1 |
| Susan Horton | 1 | |
| Cedric Smith | Elliot Winthrop | 1 |
| Roy Lewis | Jordan | 1 |
| Shira Scott Astrof | Sam | 1 |
| Sharron Matthews | Waitress | 1 |
| David Collins | Copy Center Manager | 1 |
| Sam Kalilieh | 1 | |
| Hamish McEwan | Daniel McGuire | 1 |
| Bobby Manning | Employee | 1 |
| Robert Morelli | Andy McMahon | 1 |
| Julia Chantrey | Sydney | 1 |
| Christopher B. MacCabe | Guard / Captain | 1 |
| Jean Daigle | Agent in Charge | 1 |
| Clé Bennett | Doug Moses | 1 |
| Melissa Bray | Girl | 1 |
| Gary Gerbrandt | Rat Gang Member | 1 |
| Brian Rhodes | High Stakes Gambler | 1 |
| Russell Yuen | Michael Yu | 1 |