| Name | Character | Episodes |
|---|---|---|
| Kristin Kreuk | Laurel Yeung | 70 |
| Grace Park | Shannon Ng | 70 |
| Sarah Lind | Jen MacMahon | 70 |
| P.J. Prinsloo | Chris Laidlaw | 70 |
| Dominic Zamprogna | Mark Deosdade | 70 |
| Meghan Black | Kat Deosdade | 57 |
| Richard Kahan | Gil Kurvers | 57 |
| Daniella Evangelista | Tracet Antonelli | 57 |
| James Kirk | 38 | |
| Chiara Zanni | 38 | |
| Jessica Lucas | Becca Lawrence | 31 |
| Jessica Lucas | 15 | |
| Chiara Zanni | Maggie Buckman | 13 |
| Myles Ferguson | Scott Linton | 13 |
| John Reardon | Josh Wyatt | 11 |
| Daniella Evangelista | 11 | |
| Sarah Edmondson | 9 | |
| Chelan Simmons | 8 | |
| Richard Kahan | 8 | |
| Tyron Leitso | 7 | |
| Matthew Currie Holmes | 7 | |
| Sage Brocklebank | 2 | |
| Zahf Paroo | 2 | |
| Bif Naked | 2 | |
| Michael Adamthwaite | 1 |