| Name | Character | Episodes |
|---|---|---|
| Wil Wheaton | Self - Host | 4 |
| Mica Burton | Self - Host | 3 |
| Alexander Siddig | Self | 2 |
| Nana Visitor | Self | 2 |
| Terry Farrell | Self | 2 |
| Ira Steven Behr | Self | 2 |
| Cirroc Lofton | Self | 2 |
| Jack Quaid | Self | 1 |
| Patrick Stewart | Self | 1 |
| Kate Mulgrew | Self | 1 |
| John Billingsley | Self | 1 |
| Robert Duncan McNeill | Self | 1 |
| Ethan Phillips | Self | 1 |
| Alex Kurtzman | Self | 1 |
| Robert Picardo | Self | 1 |
| Sonequa Martin-Green | Self | 1 |
| Linda Park | Self | 1 |
| Jonathan Frakes | Self | 1 |
| Armin Shimerman | Self | 1 |
| Scott Bakula | Self | 1 |
| Eugene Cordero | Self | 1 |
| Dominic Keating | Self | 1 |
| Anthony Montgomery | Self | 1 |
| Tawny Newsome | Self | 1 |
| Connor Trinneer | Self | 1 |
| Tim Russ | Self | 1 |
| David Ajala | Self | 1 |
| Mike McMahan | Self | 1 |
| Noël Wells | Self | 1 |