| Name | Character | Episodes |
|---|---|---|
| Jennie Jacques | Annie Miller | 6 |
| Tom Hollander | John Ruskin | 6 |
| Sam Crane | Fred Walters | 6 |
| Phil Davis | Mr. Stone | 6 |
| Rafe Spall | William Holman Hunt | 6 |
| Aidan Turner | Dante Gabriel Rossetti | 6 |
| Maimie McCoy | Margaret | 6 |
| Mark Heap | Charles Dickens | 6 |
| Zoë Tapper | Effie Ruskin/ Effie Millais | 6 |
| Amy Manson | Lizzie Siddal | 6 |
| Samuel Barnett | John Millais | 6 |
| Peter Sandys-Clarke | Edward Burne-Jones | 6 |
| Mark Benton | 2 | |
| Samuel West | 1 | |
| Richenda Carey | 1 |