| Name | Character | Episodes |
|---|---|---|
| Georgie Parker | Terri Sullivan | 335 |
| Tammy Macintosh | Charlotte Beaumont | 282 |
| Libby Tanner | Bronwyn Craig | 254 |
| Erik Thomson | Mitch Stevens | 253 |
| John Howard | Frank Campion | 239 |
| Brian Vriends | Ben Markham | 209 |
| Christopher Gabardi | Vincent Hughes | 205 |
| Wil Traval | Jack Quade | 202 |
| Mark Priestley | Dan Goldman | 202 |
| Conrad Coleby | Scott Zinenko | 169 |
| Alexandra Davies | Cate McMasters | 159 |
| Jolene Anderson | Erica Templeton | 158 |
| Sam Healy | Jaz Hillerman | 84 |
| Jenni Baird | Paula Morgan | 84 |
| Andrew McKaige | Peter Morrison | 84 |
| Chris Vance | Sean Everleigh | 81 |
| John Waters | Mike Vlasek | 81 |
| Virginia Gay | Gabrielle Jaegar | 81 |
| Ella Scott Lynch | Claire Anderson | 77 |
| Mirrah Foulkes | Jo Mathieson | 37 |
| Ling Cooper Tang | Kylie Preece | 31 |
| Celia Ireland | Regina Butcher | 27 |
| Joy Smithers | Rose Carleton | 18 |
| John Noble | Mr Madsen | 15 |
| Justine Clarke | Samantha O'Hara | 14 |
| Belinda Emmett | Jodi Horner | 13 |
| Rod Mullinar | Prof. Richard Craig | 9 |
| Damon Herriman | Danny Bucknell | 8 |
| Peter Lamb | Neil Phillips | 8 |
| John Noble | John Madsen | 7 |
| Melissa Jaffer | Eileen Sullivan | 7 |
| Joy Smithers | Rose Stevens | 6 |
| Michael Caton | Bob Parkin | 6 |
| Pia Miranda | Brittany Finlay | 6 |
| Sonia Todd | Kate Larsen | 6 |
| Justine Clarke | Dr Samantha O'Hara | 6 |
| Linda Newton | Jenny Morrison | 5 |
| Helen Dallimore | Amanda Sales | 5 |
| Ling Cooper Tang | Dr Kylie Preece | 5 |
| Marta Dusseldorp | Debbie Bloom | 4 |
| Zoe Carides | Sarah Adams | 4 |
| Peter Collingwood | Lionel Macken | 4 |
| Martin Vaughan | Ryan Sullivan | 4 |
| Eric Bana | Rob Biletsky | 3 |
| Arianthe Galani | Gilda Poletti | 3 |
| Liz Burch | Di Richards | 3 |
| Scott Major | Jason Richard | 3 |
| Lynette Curran | Hilary Doyle | 3 |
| Pippa Grandison | Simone Carlisle | 3 |
| Tony Barry | Frank O'Hara | 3 |
| Kym Wilson | Raelene Gregson | 3 |
| Betty Lucas | Sister Bernard | 3 |
| John Adam | Tom Snowden | 3 |
| Sonia Todd | Kate Larson | 3 |
| Mary Acres | Deidre Macken | 3 |
| Michelle Boyle | Ella | 3 |
| Bill Young | Owen Doyle | 3 |
| Jason Clarke | Eddie Furlong | 2 |
| Kristian Schmid | Thomas Ferry | 2 |
| Grant Bowler | Darren Rigg | 2 |
| Bill Hunter | Ron Williams | 2 |
| Terry Serio | Greg Costello | 2 |
| Anthony Hayes | Krys Goretski | 2 |
| Chris Haywood | 2 | |
| Myles Pollard | Robert Ford | 2 |
| John Howard | Jonathan Healy | 2 |
| Andrew McFarlane | David Miller | 2 |
| Rebekah Elmaloglou | Justine Addison | 2 |
| Alexandra Davies | Naomi Collins | 2 |
| Natasha Beaumont | Rebecca Green | 2 |
| Bille Brown | Steve Coulter | 2 |
| Jonathan Elsom | Judge | 2 |
| Alan Cinis | Mr Higgins | 2 |
| Dina Gillespie | Maria Sanderson | 2 |
| Andy Anderson | Lewis Dowd | 2 |
| Laurence Breuls | Scott Chambers | 2 |
| John Adam | Tom Snowdon | 2 |
| Betty Bobbitt | Olivia Macreadie | 2 |
| Paul Kelman | Kevin Taylor | 2 |
| Bruce Venables | Bosco the Clown | 2 |
| Alexandra Fowler | Juliette McAllistair | 2 |
| Michael Denkha | Mario Constantine | 2 |
| Michelle Boyle | Ella Paterson | 2 |
| Bojana Novaković | Rachel Carpenter | 1 |
| Marton Csokas | Brother Thomas | 1 |
| Mia Wasikowska | 1 | |
| Sarah Snook | Sophie | 1 |
| John McTernan | Geoff Cavendish | 1 |
| Peter Callan | Graham Birch | 1 |
| Cecily Polson | June Burns | 1 |
| Alan David Lee | John Jeffries | 1 |
| John McNeill | Allan Miller | 1 |
| Wayne Pygram | Joel Wallace | 1 |
| John Noble | Dr Madsen | 1 |
| Kate Mulvany | Hayley McMasters | 1 |
| Richard Wilson | 1 | |
| Angelo D'Angelo | Damien Carr | 1 |
| Jeff Truman | Ron Monroe | 1 |
| Vincent Ball | Bill Weiner | 1 |
| Greg Ellis | SRA Worker #3 | 1 |
| Harold Hopkins | Frank Miller | 1 |
| Charles Tingwell | Dr Harry McKay | 1 |
| Damian de Montemas | Mike McGrath | 1 |
| Maggie Blinco | Berry Juniper | 1 |
| Russell Newman | Bert Petrakis | 1 |
| Drew Forsythe | 1 | |
| Lara Cox | Cathy Maxwell | 1 |
| Rene Naufahu | Gary Headley | 1 |
| Robin McLeavy | Katherine Burnett | 1 |
| Callan Mulvey | Stewie Holder | 1 |
| Greig Fraser | Courier | 1 |
| Rachael Carpani | Emily Martin | 1 |
| Tiriel Mora | Steve Cole | 1 |
| Penne Hackforth-Jones | Elise Fletcher | 1 |
| Roy Billing | Barry Croft | 1 |
| Rowena Wallace | Katrina Ford | 1 |
| Simmone Mackinnon | Krystal Woods | 1 |
| John Batchelor | Wayne Calder | 1 |
| Rhondda Findleton | Sharon Ellison | 1 |
| Marshall Napier | Mick Mason | 1 |
| Marshall Napier | Ian Hanrahan | 1 |
| Garry McDonald | Dave Armstrong | 1 |
| Michael C. Gwynne | Adam Gregson | 1 |
| Richard Carter | Alistair Walsh | 1 |
| Keiynan Lonsdale | Corey | 1 |
| Mark Lee | Chen Wai | 1 |
| Jamie Croft | Adam Buckley | 1 |
| Travis McMahon | Scott Fitzpatrick | 1 |
| Joe Petruzzi | Steve Michalandos | 1 |
| Brett Climo | Bryan Taylor | 1 |
| Wayne Blair | Kenny Baxter | 1 |
| Brittany Byrnes | Jacinta Clarke | 1 |
| Brittany Byrnes | Becky Franklin | 1 |
| John Brumpton | Steve Casey | 1 |
| Kerry Walker | Barbara Phillips | 1 |
| Ken Goodlet | Viv Brash | 1 |
| Frank Whitten | Ken Burns | 1 |
| Simone Buchanan | Mitchie Bell | 1 |
| Zoe Carides | Sarah Armstrong | 1 |
| Christine Stephen-Daly | Rachel McMahon | 1 |
| Peter Kowitz | Jimmy Frankston | 1 |
| Steve Rodgers | Dean Johnston | 1 |
| Fiona Press | Elena Freeman | 1 |
| Denise Roberts | Janice McGregor | 1 |
| Christian Manon | Smythe | 1 |
| Lauren Hewett | Tracey Hrnjack | 1 |
| Sarah Chadwick | Francesca Norman | 1 |
| Matthew Dale | Police Officer | 1 |
| Lynette Curran | Anita Petrakis | 1 |
| Ling Cooper Tang | Barbara Chan | 1 |
| Ditch Davey | Shane Joseph | 1 |
| Aaron Blabey | Scott Lacey | 1 |
| Daniel Roberts | David McLachlan | 1 |
| Jonathan Hardy | Cliff Unwin | 1 |
| Alan Cinis | Karl Updike | 1 |
| Alan Cinis | Dr Karl Updike | 1 |
| Alan Cinis | Dr Higgins | 1 |
| Anthony Jensen | Dealer | 1 |
| Luke Carroll | Seb | 1 |
| Andy Anderson | Alan Mitchell | 1 |
| Michela Noonan | Julie Allen | 1 |
| Mark Priestley | Julian Day | 1 |
| Andrea Moor | Alana Devlin | 1 |
| Brian Rooney | Robbie Watson | 1 |
| Sandy Winton | Greg Newman | 1 |
| Richard Lambeth | Mr Kennedy | 1 |
| Josh Picker | Paul Mitchell | 1 |
| Samantha Noble | Kylie Monroe | 1 |
| Mitchell Butel | Christopher Jones | 1 |
| Anthony Brandon Wong | Carlo de Sousa | 1 |
| Martin Vaughan | Arthur | 1 |
| Martin Vaughan | Arthur Frew | 1 |
| David Taylor | Priest | 1 |
| Glenn Ruehland | Christopher's Double | 1 |
| Paul Chubb | William Lucas | 1 |
| Doug Scroope | Clayton Trent | 1 |
| Daniel Amalm | Moe Atsidakos | 1 |
| Tina Bursill | Margaret Evans | 1 |
| Steve Jacobs | Dr Harry Williams | 1 |
| Steve Jacobs | Dr. Harry Williams | 1 |
| Beth Champion | Melissa | 1 |
| Simon Chilvers | Brian Toomey | 1 |
| Elena Carapetis | Patti Burke | 1 |
| Caitlin McDougall | Jodie Reeves | 1 |
| Monroe Reimers | Ashok Patel | 1 |
| David Franklin | Michael Politis | 1 |
| Daniel Kellie | Aden Calder | 1 |
| Daniel Kellie | Ashley Ciantar | 1 |
| Lyn Collingwood | Laraine Parkes | 1 |
| Louise Crawford | Lynette Newman | 1 |
| Jackson Raine | Dr James Wu | 1 |
| Jackson Raine | Dr Wu | 1 |
| Alan Flower | Dave Winton | 1 |
| Cass Cumerford | Shane Hayes | 1 |
| Cass Cumerford | Skinny Santa | 1 |
| Scott Swalwell | Alan Cameron | 1 |
| Paula Arundell | Nura Arkuna | 1 |
| Ann Burbrook | Carol Sherwood | 1 |
| Kim Lewis | Megan Costello | 1 |
| Peter Sumner | Errol Baumann | 1 |
| Tempany Deckert | Andrea Carter | 1 |
| David James | Karl Von Hunter | 1 |
| David James | Richard Davies | 1 |
| Alexandra Fowler | Juliette McAlistair | 1 |
| Rod Mullinar | Richard Craig | 1 |
| Mark Hennessy | Brian Daley | 1 |
| Mark Hennessy | Rescue Leader | 1 |
| Linden Wilkinson | Helen Upton | 1 |
| Bill Conn | Vic McArdle | 1 |
| Mick Innes | Rowan Barker | 1 |
| Belinda Emmett | Jodie Horner | 1 |
| Jo Briant | Ellen Croghan | 1 |
| Jai Koutrae | Jack | 1 |
| Julie Hamilton | Mrs Armstrong | 1 |
| Julie Hamilton | Maureen Forlano | 1 |
| Terence Crawford | Paul Roebuck | 1 |
| Barbara Gouskos | Mrs Habib | 1 |
| John Clayton | Tony Wilson | 1 |
| Nicholas Ryan | Eric Turner | 1 |
| Simon Lyndon | Will Harrington | 1 |
| Paul Mercurio | Oscar Franklin | 1 |
| Skye Wansey | Sandy Morris | 1 |
| Maya Stange | Emily Watson | 1 |
| Brendan Donoghue | Garry Richards | 1 |
| Maggie Dence | Lyn Brown | 1 |
| Leslie Dayman | Ray Hanson | 1 |
| Daniel Krige | Paul Millard | 1 |
| Leo Taylor | Barry Stoneham | 1 |
| Maurice Morgan | Abouhd | 1 |
| Chris Sadrinna | David | 1 |
| Stephen Leeder | Mr Jamieson | 1 |
| Sarah Aubrey | Amanda Morton | 1 |
| Julie Sobotta | Tick Harpur | 1 |
| Michelle Boyle | ICU Nurse | 1 |
| Michelle Boyle | Nurse | 1 |
| Stephen Holt | Police Officer | 1 |
| Yanna Black | Mary Sendaris | 1 |
| Andrew Crabbe | Samuel Tennant | 1 |
| Leanna Brockenshire | Natalie Everly | 1 |
| Amanda Wenban | Sarah Constantini | 1 |
| Brian Langsworth | Chorister | 1 |
| Tanya Lawson | Elise Poulos | 1 |
| Tahir Bilgiç | Mr Mustafa | 1 |
| Morgan O'Neill | Roger Fleming | 1 |
| Bill Young | Don McClusky | 1 |
| Danielle Spencer | Kate Taylor | 1 |
| Nicholas Papademetriou | Marco Vuga | 1 |
| Peter Heath | Fire Captain | 1 |
| Justine Clarke | Dr. Samantha O'Hara | 1 |
| Ian Meadows | Jeff Weiss | 1 |