| Name | Character | Episodes |
|---|---|---|
| Dennis O'Keefe | Self - Host | 42 |
| Roddy McDowall | 2 | |
| Jack Klugman | 2 | |
| Sebastian Cabot | Mr. Podgers | 2 |
| Janice Rule | 2 | |
| Kent Smith | Dr. Jonathan Michel, the Psychiatrist | 2 |
| Charles Bronson | Cal | 1 |
| James Coburn | Matt Carson | 1 |
| Harry Dean Stanton | Bill | 1 |
| Eli Wallach | 1 | |
| William Shatner | Eli | 1 |
| Michael Landon | Howard | 1 |
| Audie Murphy | Steve Gordon | 1 |
| Dan Duryea | Eddie Schumaker / McDillard | 1 |
| Andrew Duggan | Al Guthrie | 1 |
| Dane Clark | 1 | |
| Dee J. Thompson | Receptionist | 1 |
| Marion Lorne | Mrs. Foster | 1 |
| James Daly | 1 | |
| Burgess Meredith | Ramskill | 1 |
| Donna Reed | Letty Jason | 1 |
| Elizabeth Montgomery | Ellen | 1 |
| Michael Rennie | Angus Martin | 1 |
| Jack Warden | Charlie Hayes | 1 |
| Denholm Elliott | 1 | |
| John Ireland | 1 | |
| Ralph Bellamy | Detective Thorpe | 1 |
| Pat Hingle | Calman | 1 |
| Warren Beatty | Boy | 1 |
| Rod Taylor | Jim | 1 |
| Lorne Greene | Monty | 1 |
| Rod Steiger | Frank Marre | 1 |
| Ray Milland | Roy Markham | 1 |
| Joseph Cotten | Gregg Carey | 1 |
| Boris Karloff | Judge Winthrop Gelsey | 1 |
| Edmond O'Brien | Sgt. Miles Odeen | 1 |
| Rory Calhoun | Peter Lockwood | 1 |
| Jessica Tandy | 1 | |
| John Williams | Col. Selby | 1 |
| John Carradine | Raphael | 1 |
| Fred Gwynne | Hughie | 1 |
| Agnes Moorehead | Katherine Searles | 1 |
| Jack Klugman | Jason | 1 |
| Warren Stevens | 1 | |
| E.G. Marshall | Paul Steppe | 1 |
| Ross Martin | 1 | |
| Rosemary Harris | Sybil Merton | 1 |
| Harry Guardino | Larry Gennaro | 1 |
| Henry Silva | Dick | 1 |
| Anthony Quayle | Graham | 1 |
| Barbara Rush | Eleanor Thomason | 1 |
| Patrick Macnee | Captain John Biersdorf | 1 |
| Edie Adams | Gloria Chrystie | 1 |
| Claudette Colbert | Edith Miller | 1 |
| Macdonald Carey | Jeremiah Taylor | 1 |
| John Mitchum | 1 | |
| Bette Davis | Mrs. Wilfred Ellis | 1 |
| Gary Merrill | 1 | |
| Joseph Wiseman | 1 | |
| Jan Sterling | Georgiana | 1 |
| Marian Seldes | 1 | |
| Skip Ward | Ralph Newcombe, Jr. | 1 |
| Edward Andrews | Carl | 1 |
| Philip Tonge | Ralph Newcombe, Sr. | 1 |
| Thayer David | Turko | 1 |
| Jane Greer | Clare Stengler | 1 |
| Mary Forbes | Mrs. Merton | 1 |
| Lomax Study | Hotel Clerk | 1 |
| Kurt Kasznar | 1 | |
| Robert Flemyng | Nigel Crossley | 1 |
| Larry Parks | Dr. Milt Krop | 1 |
| Harry Tyler | Daly, the Driver | 1 |
| Pamela Brown | Solange Rogers | 1 |
| Janice Rule | Kelly Pomeroy | 1 |
| David Wayne | James Mennick | 1 |
| Phyllis Thaxter | Flora | 1 |
| Phyllis Thaxter | 1 |