| The story centers on Keitarou Gentouga, who has the ability to be a spirit medium. In junior high school, he got someone else wrapped up in a spirit possession incident, and he has been a shut-in for more than two years. As he reintroduces himself to society as a private tutor, he meets a genius girl named Yayoi Houzuki. Yayoi is instantly able to tell that Keitarou has skill as a spirit medium, and she invites him to go with her to a haunted location. The two then start their journey capturing evil spirits. | 
| Name | Character | Episodes | 
|---|---|---|
| Kana Hanazawa | Eiko Hozuki (voice) | 25 | 
| Nobunaga Shimazaki | Keitaro Gentoga (voice) | 25 | 
| Yoshihiro Nakamura | Narrator (voice) | 25 | 
| Taku Yashiro | Oswald (voice) | 5 | 
| Saori Hayami | Castle H Ruins spirit (voice) | 4 | 
| Hochu Otsuka | Alien doll spirit (voice) | 4 | 
| Yoko Hikasa | Courtesan Otogiri Oiran (voice) | 3 | 
| Yukari Tamura | Anna Misaki (voice) | 3 | 
| Masashi Ebara | Nankobo (voice) | 3 | 
| Yoshitsugu Matsuoka | Old Old F Tunnel spirit (voice) | 2 | 
| Reina Ueda | Daughter's spirit (voice) | 2 | 
| Mitsuo Iwata | Brainstem spirit (voice) | 2 | 
| Aya Hisakawa | Namiko Shami (voice) | 2 | 
| Shinichiro Kamio | Teacher (voice) | 1 | 
| Daiki Hamano | Priest wearing sunglasses (voice) | 1 | 
| Aya Hisakawa | Nagiko Shami (voice) | 1 | 
| Kazuyuki Okitsu | Nagayama / Kyo Machida (voice) | 1 | 
| Eiko Yamada | Woman (voice) | 1 |