| After the death of his wife, world-class neurosurgeon Dr. Andrew Brown leaves Manhattan and moves his family to the small town of Everwood, Colorado. There he becomes a small-town doctor and learns parenting on the fly as he raises his talented but resentful 15-year-old son Ephram and his 9-year-old daughter Delia. |
| Name | Character | Episodes |
|---|---|---|
| Chris Pratt | Bright Abbott | 89 |
| Emily VanCamp | Amy Abbott | 89 |
| Treat Williams | Andrew Brown | 89 |
| Gregory Smith | Ephram Brown | 89 |
| Tom Amandes | Harold Abbott | 89 |
| Vivien Cardone | Delia Brown | 89 |
| Debra Mooney | Edna Harper | 89 |
| John Beasley | Irv Harper | 89 |
| Stephanie Niznik | Nina Feeney | 82 |
| Merrilyn Gann | Rose Abbott | 76 |
| Sarah Drew | Hannah Rogers | 38 |
| Scott Wolf | Jake Hartman | 38 |
| Jan Broberg | Louise | 32 |
| Sarah Lancaster | Madison Kellner | 18 |
| Marcia Cross | Linda Abbott | 18 |
| Mike Erwin | Colin Hart | 16 |
| Justin Baldoni | Reid Bardem | 15 |
| Lee Garlington | Brenda Baxworth | 13 |
| Nancy Everhard | Sharon Hart | 13 |
| Nora Zehetner | Laynie Hart | 12 |
| Anne Heche | Amanda Hayes | 10 |
| Micaela Nelligan | Martha Thompson | 10 |
| Paul Wesley | Tommy Callahan | 9 |
| Michael Flynn | James Hart | 8 |
| Steven R. McQueen | Kyle Hunter | 7 |
| Jason Beghe | John Hayes | 6 |
| Lukas Behnken | Topher Cole | 6 |
| Charlie Weber | Jay | 5 |
| Freda Foh Shen | Dr. Chao | 5 |
| Brenda Strong | Julia Brown | 4 |
| Scott Christopher | Coach Austin | 4 |
| Bret Loehr | Magilla | 4 |
| Shane Haboucha | Charlie Hayes | 4 |
| Ben Weber | Chris Beals | 4 |
| James Earl Jones | Will Cleveland | 3 |
| Leslie Hope | Laurie Fields | 3 |
| Beth Grant | Miss Violet | 3 |
| Kelly Carlson | Ada | 3 |
| Dylan Walsh | Carl Feeney | 3 |
| Tim DeKay | Reverend Keyes | 3 |
| Jimmy Bennett | Sam Feeney | 3 |
| Robert Peters | Marty Maxwell | 3 |
| Luciana Carro | Stephanie Meyer | 3 |
| Philip Baker Hall | Dr. Donald Douglas | 3 |
| Kate Mara | Kate Morris | 2 |
| Jane Krakowski | Dr. Gretchen Trott | 2 |
| Erinn Hayes | Mindy Wheeler | 2 |
| Tom Parker | Brian Hartman | 2 |
| Charles Durning | Eugene Brown | 2 |
| Kirsten Nelson | Ellie Beals | 2 |
| Michelle Nolden | Kathy Carmody | 2 |
| Richard Herd | Herb Roberts | 2 |
| John Savage | Daniel Maxwell | 2 |
| Betty White | Carol Roberts | 2 |
| Jodi Russell | Debbie West | 2 |
| Mark Rydell | Jacob Hoffman | 2 |
| Doris Belack | Ruth Hoffman | 2 |
| Joel Bishop | The Pharmacist | 2 |
| Jayne Brook | Mrs. Rogers | 2 |
| Christopher Egan | Nick Bennett | 2 |
| Albie Selznick | Dr. Albert Franco | 2 |
| Monnae Michaell | Madeleine | 2 |
| Annie Burgstede | Pippi | 2 |
| Oscar Rowland | Mort | 2 |
| Philipp Karner | Josh Walker | 2 |
| Austin Tichenor | Dr. Bass | 2 |
| Victoria Mallory | Mrs. Dudley | 2 |
| Bruce Newbold | Dan Clark | 2 |
| Susanne Sutchy | Jessica Hunter | 2 |
| Rhett Willman | Mr. Perch | 2 |
| Eyal Podell | Justin | 2 |
| Victoria Justice | Thalia Thompson | 1 |
| J.K. Simmons | Phil Drebbles | 1 |
| Elizabeth Mitchell | Sara Beck | 1 |
| Joanna Cassidy | Evelyn Rowser | 1 |
| Kristen Bell | Stacey Wilson | 1 |
| Keith David | Brian | 1 |
| Nia Long | Cassie | 1 |
| Margo Harshman | Maura | 1 |
| Ryan Hurst | Ed Carnahan | 1 |
| Adam Beach | Mr. Grey Cloud | 1 |
| Kevin Tighe | Joe Morris | 1 |
| Patrick Fabian | Dr. Henry Validor | 1 |
| Sean Mahon | Pseudo Patient | 1 |
| Simon Rex | Cliff Fenton | 1 |
| Melinda Clarke | Sally Keyes | 1 |
| Obba Babatundé | Jason | 1 |
| Derek Webster | FBI Agent | 1 |
| Jessica Tuck | Bonnie | 1 |
| Lamont Thompson | Brian | 1 |
| Beau Bridges | Daniel Sullivan | 1 |
| Chris Penn | Frank Sullivan | 1 |
| Ernie Hudson | Bill Hoover | 1 |
| Camille Guaty | Serena | 1 |
| Tamara Taylor | Dr. Lence | 1 |
| Elaine Kagan | Angela Bardem | 1 |
| Renée Taylor | Betty Barrett | 1 |
| McNally Sagal | Adoption Agency Evaluator | 1 |
| John Aylward | Walter Cunningham | 1 |
| K.C. Clyde | Future Achiever | 1 |
| Gedde Watanabe | Art | 1 |
| Dendrie Taylor | Mrs. Thomson | 1 |
| Douglas Smith | Gavin Curtis | 1 |
| Olesya Rulin | The Drunk Girl | 1 |
| Claudia Christian | Young Edna | 1 |
| Gina Hecht | Gastroenterologist | 1 |
| Jess Weixler | Nikki | 1 |
| Joseph Bologna | Max Barrett | 1 |
| Joan McMurtrey | Mrs. Curtis | 1 |
| Scott Christopher | The Do-Gooder | 1 |
| Bill Erwin | Ollie | 1 |
| Justin Kirk | James Carmody | 1 |
| Tom Virtue | Juilliard Administrator | 1 |
| Christopher Neiman | Coach Lewis | 1 |
| Amy Rutberg | Sarah | 1 |
| Reiley McClendon | Travis | 1 |
| Todd Louiso | Equipment Buyer | 1 |
| Brian Baumgartner | Contractor | 1 |
| Gina Ravera | Stacey | 1 |
| Gary Basaraba | Mr. Curtis | 1 |
| Adam Huss | Waiter | 1 |
| Erica Gimpel | Dr. Gans | 1 |
| Carter Jenkins | David Beck | 1 |
| Allan Groves | Chris | 1 |
| Chris Owen | Pierson | 1 |
| Brooke Nevin | Ellie | 1 |
| David Eigenberg | Chris Templeman | 1 |
| Erick Avari | James Gellar | 1 |
| Melinda Page Hamilton | Mary Kelly | 1 |
| Brooke Bloom | College Guide | 1 |
| Diane Delano | Mary | 1 |
| Jessica Collins | Cameron | 1 |
| Laura Regan | Ruth | 1 |
| Drew Osborne | Swimmer | 1 |
| Tom Wright | Carl's Lawyer | 1 |
| Rob Nagle | Joel Hurwitz | 1 |
| Elizabeth Bond | Kate | 1 |
| Leslie Wing | Registration Woman | 1 |
| Denise Dowse | Laura Hoover | 1 |
| Gregory Alan Williams | James Cleveland | 1 |
| Kim Morgan Greene | Mrs. Thompson | 1 |
| Keone Young | Gino | 1 |
| Cheryl White | Mrs. Wilson | 1 |
| Annie O'Donnell | Librarian | 1 |
| Ryne Sanborn | Young Colin Hart | 1 |
| Trevor Wright | Student #1 | 1 |
| Luke Askew | Marvin Harrison | 1 |
| Maggie Baird | Mrs. Harcourt | 1 |
| Colleen Flynn | Chief of Human Resources | 1 |
| Joey Miyashima | Dr. Friesen | 1 |
| Stephen Spinella | Father Patrick | 1 |
| Ivey Lloyd | Shannon | 1 |
| Kellie Waymire | Helen McGinns | 1 |
| Kirby Heyborne | Mr. Perkins | 1 |
| Matthew Bellows | MRI Technician | 1 |
| Sam Littlefield | Guy | 1 |
| Yolanda Stange | The Nurse | 1 |
| Hosea Chanchez | Student | 1 |
| Alesandra Durham | Emily | 1 |
| Scott Williamson | Coach | 1 |
| Bernie Diamond | Charlie | 1 |
| Wayne Dalglish | Young Bright Abbott | 1 |
| Joyce Cohen | Millie Sullivan | 1 |
| Joyce Cohen | Princetown Rep | 1 |
| Reggie Austin | Andre Harvey | 1 |
| Michael Todd Behrens | Gerry Block | 1 |
| Melinda Renee | Concierge | 1 |
| Melinda Renee | Juilliard Registrar | 1 |
| Brian Palermo | Rick | 1 |
| Ruby Chase O'Neil | Penny | 1 |
| Preston Sadleir | EMT #2 | 1 |
| Michael McLafferty | Dave | 1 |
| Anne Sward | Ms. Caleb | 1 |
| Anne Sward | Teacher | 1 |
| Derek Boone | Todd | 1 |
| Mowava Pryor | Circulating Nurse | 1 |
| George Sullivan | Earl | 1 |
| Tom Markus | The Rabbi | 1 |
| James Jamison | Bypass Technician | 1 |
| James Jamison | Dr. Berdell | 1 |
| Frank Gerrish | Baker | 1 |
| Amy Stewart | Dr. Parsons | 1 |
| Paul Kiernan | Dr. Castle | 1 |
| Paul Kiernan | Dr. Mason Lewis | 1 |
| Tim Threlfall | Priest | 1 |
| Tim Threlfall | The Pharmacist | 1 |
| JJ Neward | Minnie | 1 |
| Terence Goodman | Winston | 1 |
| Bruce Newbold | Male Board Member | 1 |
| Bruce Newbold | Councilman Morris | 1 |
| Paul Anthony McLean | Coach Spitzer | 1 |
| Phillip Jeanmarie | Pete Boroni | 1 |
| K. Danor Gerald | The MC | 1 |
| Eric Ian Goldberg | Ben O'Connell | 1 |
| Austin Archer | County Kid | 1 |
| Lincoln Hoppe | Aldo | 1 |
| Curt Doussett | Police Officer | 1 |
| Rachel Thorp | Young Amy Abbott | 1 |
| Kathryn Joosten | Mrs. Hammerhill | 1 |
| Lisa Howard | Leslie Hammond | 1 |
| Walter Olkewicz | Mike O'Connell | 1 |
| Tegan West | Jerry McGinns | 1 |
| Nora Burns | The Receptionist | 1 |
| Reb Fleming | The Camper | 1 |
| Noah Bastian | The Guy | 1 |
| Michael Coe | Clueless Student | 1 |
| Michael Coe | New Lifeguard | 1 |
| Michael Coe | Future Alcoholic | 1 |
| Slate Holmgren | Mover | 1 |