| Name | Character | Episodes |
|---|---|---|
| Hayden Panettiere | Claire Bennet | 78 |
| Milo Ventimiglia | Peter Petrelli | 78 |
| Jack Coleman | Noah Bennet | 78 |
| Adrian Pasdar | Nathan Petrelli | 78 |
| Masi Oka | Hiro Nakamura | 78 |
| Sendhil Ramamurthy | Mohinder Suresh | 78 |
| Greg Grunberg | Matt Parkman | 78 |
| James Kyson | Ando Masahashi | 78 |
| Zachary Quinto | Gabriel "Sylar" Gray | 70 |
| Cristine Rose | Angela Petrelli | 63 |
| Noah Gray-Cabey | Micah Sanders | 59 |
| Ali Larter | Tracy Strauss | 44 |
| Santiago Cabrera | Isaac Mendez | 42 |
| Ashley Crow | Sandra Bennet | 39 |
| Dania Ramirez | Maya Herrera | 36 |
| Ali Larter | Niki Sanders | 34 |
| Leonard Roberts | D.L. Hawkins | 25 |
| Tawny Cypress | Simone Deveaux | 23 |
| Randall Bentley | Lyle Bennet | 23 |
| Lisa Lackey | Janice Parkman | 22 |
| Brea Grant | Daphne Millbrook | 21 |
| Robert Knepper | Samuel Sullivan | 19 |
| Kristen Bell | Elle Bishop | 18 |
| George Takei | Kaito Nakamura | 17 |
| Dawn Olivieri | Lydia | 16 |
| Zeljko Ivanek | Emile Danko | 16 |
| David Anders | Adam Monroe | 16 |
| Adair Tishler | Molly Walker | 16 |
| Thomas Dekker | Zach | 14 |
| Stephen Tobolowsky | Bob Bishop | 14 |
| Madeline Zima | Gretchen Berg | 13 |
| Ntare Guma Mbaho Mwine | Usutu | 13 |
| Jessalyn Gilsig | Meredith Gordon | 12 |
| Elisabeth Röhm | Lauren Gilmore | 12 |
| Jamie Hector | Benjamin "Knox" Washington | 12 |
| Ray Park | Edgar | 12 |
| David H. Lawrence XVII | Eric Doyle | 12 |
| Nicholas D'Agosto | West Rosen | 11 |
| Deanne Bray | Emma Coolidge | 11 |
| Dana Davis | Monica Dawson | 11 |
| Malcolm McDowell | Daniel Linderman | 10 |
| Clea DuVall | Audrey Hanson | 10 |
| Robert Forster | Arthur Petrelli | 10 |
| Blake Shields | Flint Gordon | 10 |
| Nora Zehetner | Eden McCain | 9 |
| Shalim Ortiz | Alejandro Herrera | 9 |
| Eric Roberts | Thompson | 8 |
| Todd Stashwick | Eli | 8 |
| Danielle Savre | Jackie Wilcox | 8 |
| Saemi Nakamura | Kimiko Nakamura | 8 |
| Missy Peregrym | Candice Wilmer | 7 |
| Sasha Pieterse | Amanda Strazzulla | 7 |
| Alan Blumenfeld | Maury Parkman | 7 |
| Deirdre Quinn | Tina | 7 |
| Assaf Cohen | Hesam | 7 |
| Rena Sofer | Heidi Petrelli | 6 |
| Holt McCallany | Ricky | 6 |
| Christopher Eccleston | Claude | 6 |
| Jackson Wurth | Monty Petrelli | 6 |
| Jayma Mays | Charlene "Charlie" Andrews | 6 |
| Nichelle Nichols | Nana Dawson | 6 |
| Dominic Keating | Will | 6 |
| Adetokumboh M'Cormack | Tuko | 6 |
| Sally Champlin | Waitress Lynette | 6 |
| Joshua Rush | Little Sylar | 6 |
| Eriko Tamura | Yaeko | 6 |
| Matt Lanter | Brody Mitchum | 5 |
| Barry Shabaka Henley | Detective Bryan Fuller | 5 |
| Eugene Byrd | Campaign Manager | 5 |
| Dianna Agron | Debbie Marshall | 5 |
| Richard Roundtree | Charles Deveaux | 5 |
| Janel Parrish | May | 5 |
| Rick Worthy | Mike | 5 |
| Colby French | Hank | 5 |
| Taylor Cole | Rachel Mills | 4 |
| Francis Capra | Jesse Murphy | 4 |
| Ellen Greene | Virginia Grey | 4 |
| Ron Perkins | Doctor | 4 |
| Josh Clark | Sheriff | 4 |
| Rachel Melvin | Annie | 4 |
| Julian De La Celle | Young Samuel | 4 |
| Stana Katic | Hana Gitelman | 3 |
| Seth Green | Sam | 3 |
| Missi Pyle | Hope | 3 |
| Tessa Thompson | Rebecca Taylor | 3 |
| Tamlyn Tomita | Ishi Nakamura | 3 |
| Bill Fagerbakke | S.R. Gustavson | 3 |
| Michael Dorn | U.S. President | 3 |
| Ernie Hudson | Captain Lubbock | 3 |
| Stacy Haiduk | Elisa Thayer | 3 |
| Dan Byrd | Luke Campbell | 3 |
| Demetrius Grosse | Baron Samedi | 3 |
| Ravi Kapoor | Young Dr. Chandra Suresh | 3 |
| Carlon Jeffery | Damon Dawson | 3 |
| Bruce Boxleitner | Robert Malden | 3 |
| Erick Avari | Chandra Suresh | 3 |
| Chad Faust | Scott | 3 |
| Cary-Hiroyuki Tagawa | The Swordsmith | 3 |
| Jordan Dang | Young Ando | 3 |
| Wes Ramsey | Roy the Waterboy | 3 |
| Carlease Burke | Nurse Hammer | 3 |
| Ronald Guttman | Dr. Zimmerman | 3 |
| Jack Wallace | Arnold | 3 |
| Kat Purgal | Allison | 3 |
| Karri Turner | Lisa | 3 |
| Doug Haley | Young Joseph | 3 |
| Franc Ross | Danny Pine | 3 |
| Rick Peters | Tom McHenry | 3 |
| Shishir Kurup | Nirad | 3 |
| Link Baker | Broken Nose Guard | 3 |
| Joel West | Agent Daniel Simmons | 3 |
| Justin Baldoni | Alex Woolsey | 2 |
| Joanna Cassidy | Victoria Pratt | 2 |
| Blair Hickey | Bank Manager | 2 |
| Elizabeth Ann Bennett | Sue Landers | 2 |
| Adam Lazarre-White | Ian Michaels | 2 |
| Laura Marano | Young Alice Shaw | 2 |
| Louise Fletcher | Dr. Coolidge | 2 |
| Stan Lee | Bus Driver | 2 |
| Lyndsy Fonseca | April | 2 |
| Diana Scarwid | Alice Shaw | 2 |
| Paula Newsome | Dr. Witherson | 2 |
| Alexa Nikolas | Angela Shaw | 2 |
| Edwin Hodge | Young Charles Deveaux | 2 |
| Candice Patton | Olivia | 2 |
| Kate Vernon | Vanessa Wheeler | 2 |
| Mark L. Young | Jeremy Greer | 2 |
| Cory Hardrict | Hype Wilson | 2 |
| Lauren Stamile | Ms. Gerber | 2 |
| Breckin Meyer | Frack | 2 |
| Zachary Quinto | 2 | |
| Sakina Jaffrey | Mrs. Suresh | 2 |
| Swoosie Kurtz | Millie Houston | 2 |
| Brian Tarantina | Weasel | 2 |
| Olga Sosnovska | Angela's Aide | 2 |
| James Kyson | 2 | |
| Andre Royo | Stephen Canfield | 2 |
| Joe Bucaro III | Hazmat #1 | 2 |
| Gabriel Olds | Agent Taub | 2 |
| Rusty Schwimmer | Dale Smither | 2 |
| Elya Baskin | Ivan Spector | 2 |
| Jeanette Brox | Camille | 2 |
| Stephen Spinella | Oliver Dennison | 2 |
| Daniel Newman | Jimmy Keppler | 2 |
| Keisuke Hoashi | Japanese Cop | 2 |
| Kiko Ellsworth | Echo DeMille | 2 |
| Nicole Bilderback | Ms. Sakamoto | 2 |
| Karl T. Wright | Principal Marks | 2 |
| Javin Reid | Sanjog Iyer | 2 |
| Andrew Connolly | Joseph Sullivan | 2 |
| Japheth Gordon | Agent #1 | 2 |
| Geno Monteiro | Petrelli Aide | 2 |
| Kurando Mitsutake | White Beard | 2 |
| Dawn-Lyen Gardner | Elizabeth | 2 |
| Ashlee Gillespie | Lori Trammel | 2 |
| Natalina Maggio | Cheerleader | 2 |
| Kavi Ladnier | Mira Shenoy | 2 |
| Bernadette Speakes | Waitress | 2 |
| Scott Lowell | Professor | 2 |
| Kazumi Aihara | Japanese Woman | 2 |
| Greg Zola | Roy | 2 |
| Ken Lally | The German | 2 |
| Reginald James | Agent Harper | 2 |
| Mark Allan Stewart | High Roller | 2 |
| Danica Stewart | Ashley | 2 |
| Maximillian Decker | Officer johnson | 2 |
| Ben Murray | Rufus | 2 |
| Darryl Chan | Fake Kensei | 2 |
| Carlson Young | Chearleader #5 | 1 |
| Sydney Sweeney | Little Girl | 1 |
| Kiernan Shipka | Little Girl in Fire | 1 |
| Malcolm McDowell | 1 | |
| Clint Howard | Tom Miller | 1 |
| Kevin Alejandro | Agent Jenkins | 1 |
| Raphael Sbarge | Sheriff Werner | 1 |
| Julia Campbell | Mary Campbell | 1 |
| Moira Kelly | Abby Collins | 1 |
| Kellan Lutz | Andy | 1 |
| Aarti Mann | Shaila | 1 |
| Eijiro Ozaki | Young Kaito Nakamura | 1 |
| Greg Wrangler | Fire Chief | 1 |
| Timon Kyle Durrett | Hazmat Guy | 1 |
| Timon Kyle Durrett | Hazmat #2 | 1 |
| Akihiro Kitamura | Tadashi | 1 |
| Markus Flanagan | 1 | |
| Markus Flanagan | Federal Agent Alonzo | 1 |
| Meera Simhan | Doctor | 1 |
| Jamie Tisdale | Kelly Houston | 1 |
| Christopher May | Adam | 1 |
| Jaime Ray Newman | Young Victoria Pratt | 1 |
| Riki Lindhome | Car Rental Lady | 1 |
| William Katt | Jim McCann | 1 |
| Loren Lester | ER Doctor | 1 |
| Antonio Fargas | Ezekiel | 1 |
| Óscar Gutiérrez | Himself | 1 |
| Jake McLaughlin | Sligo | 1 |
| John Ross Bowie | Attorney | 1 |
| Milos Milicevic | Big Guy | 1 |
| Milos Milicevic | Hulk | 1 |
| Mark Harelik | DHS Officer | 1 |
| Thomas Robinson | Noah | 1 |
| Sage Kirkpatrick | Neighbor's Wife | 1 |
| Michael B. Silver | Liam Samuels | 1 |
| Roberto 'Sanz' Sanchez | Police Officer #1 | 1 |
| Roberto 'Sanz' Sanchez | Secret Service Agent #1 | 1 |
| John Glover | Samson Gray | 1 |
| Paul Ganus | Primatech Agent | 1 |
| Sabrina Perez | Gloria | 1 |
| David S. Jung | Courier Fanboy | 1 |
| Gerardo Celasco | Gilberto | 1 |
| Paul Raci | Ernie the Weasel | 1 |
| Ned Vaughn | Agent Steve Donner | 1 |
| Mark Christopher Lawrence | Mr. Lamont | 1 |
| Rebecca Tilney | Mom | 1 |
| Tiffany Hines | Cheerleader | 1 |
| Eddie Driscoll | Uniformed Officer | 1 |
| Ned Schmidtke | Martin Gray | 1 |
| Nigel Gibbs | DC Police Lieutenant | 1 |
| Katherine Boecher | Alena | 1 |
| Kenneth Choi | Sam Douglas | 1 |
| James Devoti | Cop | 1 |
| Gina St. John | Reporter | 1 |
| David Ury | Super | 1 |
| David Ury | Landlord | 1 |
| Graham Beckel | Hal Sanders | 1 |
| Matt Bushell | Linderman's Henchman | 1 |
| Christine Adams | Dr. Madeline Gibson | 1 |
| Mercedes Colon | Police Detective | 1 |
| Carrie Wiita | Kara | 1 |
| Allison Paige | Chearleader #6 | 1 |
| Tina Lifford | Paulette Hawkins | 1 |
| Alex Fernandez | Police Captain Baldwin | 1 |
| David Atkinson | Assassin | 1 |
| Cristine Rose | 1 | |
| William Duffy | ER Doctor | 1 |
| Cory Tucker | First Agent | 1 |
| Stephen Full | Lowlife | 1 |
| Michael Reilly Burke | Detective | 1 |
| Erik Betts | Scary Guy #1 | 1 |
| Bonnie Burroughs | Female Coroner | 1 |
| Rolando Molina | Motel Clerk | 1 |
| Americus Abesamis | Black Bear | 1 |
| Cam Clarke | Radio Weather Announcer (voice) | 1 |
| Archie Kao | Doctor | 1 |
| Douglas Tait | Hunter #1 | 1 |
| John Lacy | Detective | 1 |
| Brad Greenquist | Nakamura's Henchman | 1 |
| Paul Perri | Diamond Dealer | 1 |
| Susan Angelo | Woman | 1 |
| Jon Donahue | Young Dr. Zimmerman | 1 |
| David Barrera | Federal Agent Quesada | 1 |
| Dusty Sorg | Caleb | 1 |
| Lateef Crowder | Gang Member #2 | 1 |
| John Prosky | Principal | 1 |
| Kevin Christy | Claire's Boss | 1 |
| Cole Williams | Ryan Hanover | 1 |
| Rick Scarry | Bartender | 1 |
| Stephen Monroe Taylor | Richard | 1 |
| Jared Farid Ward | Officer Mckinzie | 1 |
| Sherri Saum | Kate Bennet | 1 |
| Jason E. Kelley | Agent #1 | 1 |
| Jason E. Kelley | Agent | 1 |
| Ivonne Coll | Nidia | 1 |
| Michael Croner | Robert Bishop - 1961 | 1 |
| Christopher Mann | Male Airport Police | 1 |
| Bart McCarthy | Claremont | 1 |
| Helen Eigenberg | Nurse | 1 |
| Dan Desmond | Father Vance | 1 |
| Carl Ciarfalio | Jumpsuit | 1 |
| Jesse Heiman | Comic Shop Customer | 1 |
| Dan Warner | Skinny Cop | 1 |
| William Charlton | Cook | 1 |
| Bobby Hosea | Detective | 1 |
| Tehmina Sunny | Bridget | 1 |
| Jesse Corti | LAPD Police Captain Knox | 1 |
| Jonathan Goldstein | Male Citizen | 1 |
| Kate Connor | Nurse Jennifer | 1 |
| Chris Cleveland | Agent in 2008 | 1 |
| Sean Carrigan | Police Officer | 1 |
| Robert Mammana | Agent #2 | 1 |
| D. Elliot Woods | SWAT Officer | 1 |
| Bryan Krasner | Burly Guy | 1 |
| Mike Foy | Crackhead | 1 |
| Shane Conrad | Reporter #2 | 1 |
| Garrett Strommen | Bernie | 1 |
| Cindy Chiu | Sorority Girl | 1 |
| Tohoru Masamune | Boss at Yamagato | 1 |
| Tohoru Masamune | Mr. Egami | 1 |
| Brian Skala | David Sullivan | 1 |
| Ethan Cohn | Zane Taylor | 1 |
| Kelli Kirkland | Wendy | 1 |
| Brian Palermo | Rental Car Agent | 1 |
| Russell B. McKenzie | Beat Cop | 1 |
| Elizabeth Roberts | Holly | 1 |
| Emerson Brooks | Police Officer | 1 |
| Candace Smith | Miss Roberts | 1 |
| Christine Avila | Mother Superior | 1 |
| Bryce Hurless | Pistol Petey | 1 |
| Brian Kimmet | Copy Kingdom Manager | 1 |
| Cloie Wyatt Taylor | Aide | 1 |
| Frank Pacheco | Hess | 1 |
| Ewan Chung | Office Worker #4 | 1 |
| Irina Maleeva | Ivan's Wife | 1 |
| Jason Konopisos-Alvarez | Airport Security | 1 |
| Jayson Blair | Young Nathan | 1 |
| Clay Wilcox | Sharpshooter | 1 |
| Christina Haag | Dr. Lindale | 1 |
| Natalie Salins | Sylar's Mother | 1 |
| John Antonini | Agent #1 | 1 |
| Senyo Amoaku | Scary Guy #2 | 1 |
| Ben Cain | Museum Guard | 1 |
| Cazimir Milostan | Limo Driver | 1 |
| Adam Harrington | Paramedic | 1 |
| Nicky Endres | Asian Teen (uncredited) | 1 |
| Patrick Faucette | Fireman | 1 |
| Natalie Amenula | Healer's Daugher | 1 |
| Shane Woodson | Cowboy Boots | 1 |
| Steve Seagren | Doorman | 1 |
| Ossie Mair | Vendor | 1 |
| Edward Carnevale | Dispatcher | 1 |
| Annie McKnight | Security Agent | 1 |
| Hector Luis Bustamante | Garcia | 1 |
| Daniel Kash | Fireman | 1 |
| Anna Clark | 5 Year Old Megan | 1 |
| Shevaun Kastl | Waitress | 1 |
| John F. Schaffer | Audience Member | 1 |
| Yareli Arizmendi | Healer | 1 |
| Josh Barker | Secret Service Agent #2 | 1 |
| Toni Lewis | Medical Examiner | 1 |
| Nayo Wallace | Med Tech | 1 |
| Gregory Hoyt | Young Man | 1 |
| Matt Sigloch | Officer in Charge | 1 |
| B.J. Clinkscales | Drug Dealer | 1 |
| Wade Harlan | Agent Wade | 1 |
| John Lee Ames | Game Operator | 1 |
| Nancy McCrumb | Agent Karina | 1 |
| Amrapali Ambegaokar | Annapura | 1 |
| Meeghan Holaway | Saleswoman | 1 |
| Hank Stratton | Doug Douglas | 1 |
| Matt North | Linderman's Guard | 1 |
| Yuki Matsuzaki | Worker | 1 |
| Taira Soo | Teacher | 1 |
| Stephen W. Schriver | Guard | 1 |
| Tak Kubota | Old Monk | 1 |
| Ryan Todd | Paramedic | 1 |
| Monica Louwerens | Lady with Purse | 1 |
| Reginald James | Guard One | 1 |
| Reginald James | Agent #2 | 1 |
| Franco Vega | Police Officer | 1 |
| Angela Martinez | Andrea Charles | 1 |
| J. David Shanks | Reporter Bruce Evans | 1 |
| Ramona DuBarry | Tech | 1 |
| Zack Lively | Rahul | 1 |
| Conroe Brooks | Police Officer | 1 |
| Heather Ankeny | Beth | 1 |
| Sonalii Castillo | Marie | 1 |
| Brent Tarnol | Josh | 1 |
| Ian Gomez | 1 | |
| Ian Gomez | Art Dealer | 1 |
| David Berman | Brian Davis | 1 |
| Jack Guzman | Security Guard | 1 |
| Julie Costello | Hot Girl #1 | 1 |
| Logan Alexander | Police Officer | 1 |
| Sterling Beaumon | Crane Boy | 1 |
| K Callan | Charlie Andrews | 1 |
| Lilas Lane | Kyra | 1 |
| Peyton Hinson | Waitress | 1 |
| Jason Graham | Jason | 1 |
| China Anderson | Little Girl | 1 |
| Jarvis W. George | Patrick | 1 |
| Claudia DiFolco | Reporter | 1 |
| Shawnie Costello | Hot Girl #2 | 1 |
| Darryl Chan | White Beard's Guard | 1 |