| Set in Sydney beach suburb of Manly, New South Wales, Out of the Blue is a drama about a group of thirty-year-old friends returning home for a high school reunion, which is brought to an end when someone is murdered. An investigation follows as the group attempts to discover which one of them was the killer. | 
| Name | Character | Episodes | 
|---|---|---|
| Samara Weaving | Kirsten Mulroney | 130 | 
| Daniel Henshall | Adam 'Addo' O'Donnell | 130 | 
| Bernard Curry | Nate Perrott | 130 | 
| Nathaniel Buzolic | Paul O'Donnell | 130 | 
| Daisy Betts | Peta Lee | 130 | 
| Louis Hunter | Kyle Mulroney | 130 | 
| Zoe Carides | Pia Jones | 130 | 
| Katherine Hicks | Poppy Hammond | 130 | 
| Renai Caruso | Rebecca 'Bec' Quilter | 130 | 
| Basia A'Hern | Lucia Jones | 130 | 
| Clayton Watson | Jarrod O'Donnell | 130 | 
| Noel Hodda | Ron O'Donnell | 130 | 
| Maggie Dence | Olive Hammond | 130 | 
| Charlotte Gregg | Tracy O'Donnell | 130 |