| Name | Character | Episodes |
|---|---|---|
| Danny Thomas | Self - Host | 22 |
| Mickey Rooney | Self | 1 |
| Walter Brooke | 1 | |
| Dorothy Provine | Laura Merrill | 1 |
| Walter Pidgeon | Jason Merrill | 1 |
| Richard Kiley | 1 | |
| Joan Collins | Myra | 1 |
| Victor Buono | Hippie | 1 |
| Carolyn Jones | Stacey McCall | 1 |
| Michael Rennie | Paul Heaton | 1 |
| Dean Stockwell | Bruno | 1 |
| Robert Stack | Angelo (Businessman) | 1 |
| Mary Crosby | 1 | |
| Dean Jones | Himself | 1 |
| Barry Sullivan | Fairbanks | 1 |
| Buddy Hackett | Zeus | 1 |
| Clarence Williams III | 1 | |
| Anne Baxter | 1 | |
| Juliet Prowse | Aphrodite | 1 |
| Polly Bergen | Self | 1 |
| Strother Martin | Paul Rooney | 1 |
| George Maharis | Phil Pearson | 1 |
| Lloyd Kino | T.C. Wong | 1 |
| Red Buttons | 1 | |
| James Whitmore | Professor John Woodruff | 1 |
| Phil Silvers | Self | 1 |
| Enzo Cerusico | 1 | |
| Rick Jason | Smitty | 1 |
| Harry Harvey | Mike | 1 |
| Bill Zuckert | Stanley | 1 |
| Richard Conte | Jeff Hoffman | 1 |
| Alan Hewitt | Sam Rose | 1 |
| Herbie Faye | Night-Club Manager | 1 |
| Joseph Mell | Hook | 1 |
| Arch Johnson | Warden | 1 |
| Troy Melton | Guard | 1 |
| Robert Brown | Alan Crowley | 1 |
| Claude Johnson | Barney | 1 |
| Hal March | Nick Farrow | 1 |
| Norman Alden | Marshak | 1 |
| Janice Rule | Helen | 1 |