| Name | Character | Episodes |
|---|---|---|
| Dean Martin | Self - Host | 260 |
| Jonathan Winters | 11 | |
| Ted Knight | 4 | |
| James Stewart | 3 | |
| Buddy Ebsen | 3 | |
| Rip Taylor | 3 | |
| Howard Cosell | 3 | |
| Lena Horne | 3 | |
| Ernest Borgnine | 2 | |
| Mickey Rooney | 2 | |
| Vincent Price | 2 | |
| Dom DeLuise | 2 | |
| Buddy Hackett | 2 | |
| Carol Channing | 2 | |
| Red Buttons | 2 | |
| Steve Landesberg | 2 | |
| Avery Schreiber | 2 | |
| Lou Rawls | 2 | |
| Anna Moffo | 2 | |
| Ben Blue | 2 | |
| Leslie Uggams | 1 | |
| Dorothy Provine | 1 | |
| Elaine Stritch | 1 | |
| Irene Ryan | 1 | |
| Peter Sellers | 1 | |
| Lorne Greene | 1 | |
| Glenn Ford | 1 | |
| Rodney Dangerfield | 1 | |
| Martin Milner | 1 | |
| Peter Graves | 1 | |
| Don Rickles | 1 | |
| Polly Bergen | 1 | |
| Kay Medford | 1 | |
| Carol Lawrence | 1 | |
| June Allyson | 1 | |
| Bill Cosby | 1 | |
| Ken Berry | 1 | |
| Paul Winchell | 1 | |
| William Conrad | 1 | |
| Kent McCord | 1 | |
| Jack Burns | 1 | |
| Victor Borge | 1 | |
| Sid Caesar | 1 | |
| Jan Murray | 1 | |
| Arte Johnson | 1 | |
| Soupy Sales | 1 | |
| Leonard Barr | 1 | |
| Nipsey Russell | 1 | |
| Lou Jacobi | 1 |