| Name | Character | Episodes |
|---|---|---|
| Michael C. Hall | David Fisher | 63 |
| Lauren Ambrose | Claire Fisher | 63 |
| Frances Conroy | Ruth Fisher | 63 |
| Rachel Griffiths | Brenda Chenowith | 63 |
| Peter Krause | Nate Fisher | 63 |
| Jeremy Sisto | Billy Chenowith | 63 |
| Justina Machado | Vanessa Diaz | 63 |
| Freddy Rodríguez | Federico Diaz | 63 |
| Mathew St. Patrick | Keith Charles | 63 |
| Rainn Wilson | Arthur Martin | 26 |
| Eric Balfour | Gabe Dimas | 24 |
| Ben Foster | Russell Corwin | 24 |
| Tina Holmes | Maggie Sibley | 24 |
| Lili Taylor | Lisa Kimmel Fisher | 24 |
| Kathy Bates | Bettina | 22 |
| Joanna Cassidy | Margaret Chenowith | 21 |
| Richard Jenkins | Nathaniel Fisher | 21 |
| James Cromwell | George Sibley | 18 |
| Justin Theroux | Joe | 18 |
| Mena Suvari | Edie | 16 |
| Idalis DeLeon | Sophia | 16 |
| Peter Macdissi | Olivier Castro-Staal | 15 |
| Patricia Clarkson | Sarah O'Connor | 14 |
| Joel Brooks | Robbie | 14 |
| Ed Begley Jr. | Hiram Gunderson | 14 |
| Chris Messina | Ted Fairwell | 12 |
| Anne Ramsay | Jackie Feldman | 12 |
| Sprague Grayden | Anita Miller | 12 |
| Robert Foxworth | Dr. Bernard Chenowith | 12 |
| Kellie Waymire | Melissa | 12 |
| Peter Facinelli | Jimmy | 9 |
| Michelle Trachtenberg | Celeste | 8 |
| Catherine O'Hara | Carol Ward | 8 |
| Kevin Rankin | Johnny | 8 |
| Ricardo Chavira | Ramon | 8 |
| Eric Bruskotter | Keith's Partner | 8 |
| Bobby Cannavale | Javier | 6 |
| Glenn Fitzgerald | Aaron Buchbinder | 6 |
| Julie White | Mitzi Dalton Huntley | 6 |
| Abby Brammell | Kirsten | 6 |
| Arye Gross | Frank Muehler | 6 |
| Grant Show | Scott Axelrod | 6 |
| Wendy Schaal | Vickie Dimas | 6 |
| Lauren Birkell | Elise | 6 |
| Jeff Yagher | Hoyt | 6 |
| J.G. Hertzler | Gallery Owner | 6 |
| Lisa Banes | Victoria | 6 |
| Sean O'Bryan | Tom Wheeler | 6 |
| Jennifer Elise Cox | Mary | 6 |
| Beverly Todd | Lucille Charles | 6 |
| Julie Dretzin | Barb | 6 |
| Jessica D. Stone | Young Brenda | 6 |
| Matt Malloy | Roger Pasquese | 5 |
| Molly Parker | Rabbi Ari | 4 |
| Adam Scott | Ben Cooper | 4 |
| Vanessa Marano | Tate Pasquese | 4 |
| Michael Weston | Jake | 4 |
| Brooke Smith | Carolyn Pope | 4 |
| Stark Sands | Toby | 4 |
| James Pickens Jr. | Roderick Charles | 4 |
| Robert Pine | Basil | 4 |
| Austin Nichols | Kyle | 4 |
| Lana Parrilla | Maile | 4 |
| Illeana Douglas | Angela | 4 |
| Jenna Fischer | Sharon Kinney | 4 |
| Nolan North | Soap Actor | 4 |
| Alice Krige | Alma | 4 |
| Josh Stamberg | Sarge | 4 |
| Graham Jarvis | Bobo | 4 |
| Harriet Sansom Harris | Catherine Collins | 4 |
| Myndy Crist | Dana | 4 |
| Kimberlin Brown | Soap Actress | 4 |
| Lee Garlington | Fiona Kleinschmidt | 4 |
| Andrew Prine | Ed Kimmel | 4 |
| AJ Michalka | Ashley | 4 |
| Mary-Pat Green | Priest | 4 |
| Frank Birney | Walter Kriegenthaler | 4 |
| Larry Sullivan | Deputy Wheeler (voice) (uncredited) | 4 |
| Rosalind Chao | Cindy | 3 |
| Dean Norris | Detective Shea | 2 |
| Dina Meyer | The Widow | 2 |
| Anna Gunn | Madeline | 2 |
| Chris Pine | Young Sam Hoviak | 2 |
| Anne Dudek | Allison Williman | 2 |
| Raphael Sbarge | Father Clark | 2 |
| Wade Williams | Paul Kovitch | 2 |
| Adam Rodriguez | Kenny Simms | 2 |
| Jenny O'Hara | Garland Duncan | 2 |
| Silas Weir Mitchell | Dion Corelli | 2 |
| Michael Cudlitz | Dennis, Crossroads Leader | 2 |
| Caroline Aaron | Amelia | 2 |
| John Billingsley | Boring Man | 2 |
| George Cheung | Mr. Su | 2 |
| Shawn Hatosy | Brody Farrell | 2 |
| Kellan Lutz | Critter | 2 |
| Chris Ellis | Construction Worker #2 | 2 |
| Soledad St. Hilaire | Sophia's Neighbor | 2 |
| Margaret Easley | Young Woman in Elevator | 2 |
| Jordan Ladd | Ginnie | 2 |
| Colton James | Josh Feldman | 2 |
| Barbara Tarbuck | STD Clinic Doctor | 2 |
| Thomas Kopache | Lawrence Mason | 2 |
| Billy Lush | Paul Duncan | 2 |
| Jonathan Tucker | Bruno | 2 |
| Molly Hagan | Rachel | 2 |
| Jim Beaver | Prison Officer | 2 |
| Beth Grant | Dorothy Sheedy | 2 |
| Nicholas D'Agosto | Jonathan Gorodetsky | 2 |
| Jayma Mays | Donna | 2 |
| Sarah Lancaster | Alternate Daughter | 2 |
| Tracy Middendorf | Adele Swanson | 2 |
| Matt McCoy | Slick Funeral Director | 2 |
| Amy Hill | Madame Mana Lisa | 2 |
| Tamara Taylor | Roger's Lawyer | 2 |
| Evan Handler | Scott Philip Smith | 2 |
| Caroline Lagerfelt | Alternate Wife | 2 |
| Mark Harelik | Leonard | 2 |
| Brooke Dillman | Becky | 2 |
| Jenette Goldstein | Obstetrician | 2 |
| Alexandra Holden | Rebecca Leah 'Becky Maxwell' Milford | 2 |
| Landry Allbright | Mary Jane | 2 |
| James Morrison | Swinger Husband | 2 |
| Nicole Richie | Self | 2 |
| June Kyoto Lu | Bette Srisal | 2 |
| John Paul Pitoc | Phil | 2 |
| Judith Hoag | Dawn | 2 |
| Mare Winningham | Eileen Piper | 2 |
| Bill Cobbs | Mr. Jones | 2 |
| Leon Rippy | Daddy | 2 |
| W. Earl Brown | Pete | 2 |
| Page Kennedy | Josh Langmead | 2 |
| Jacob Vargas | Manuel 'Paco' Bolin | 2 |
| Ann Cusack | Linda Hoviak | 2 |
| Hal Ozsan | Man in Flower Shop | 2 |
| Paul Butcher | 5-Year-Old Boy | 2 |
| Joan McMurtrey | Patsy Foster | 2 |
| Tony Longo | Bitsy | 2 |
| Lucinda Jenney | Kenneth's Ex-Wife | 2 |
| Ken Davitian | Krikor Hovanessian | 2 |
| Ron Roggé | Smog Check Technician | 2 |
| Phil Reeves | Stan | 2 |
| Tom Virtue | Edward Gorodetsky | 2 |
| Chase Ellison | Young George | 2 |
| Michael Bell | Quaker Man | 2 |
| Amanda Foreman | Rebecca | 2 |
| Romy Rosemont | Professor | 2 |
| Edith Fields | Quaker Woman | 2 |
| Christopher Neiman | Medvenko | 2 |
| Terence Knox | Larry Wadd | 2 |
| Alisa Reyes | Julie | 2 |
| Terri Hoyos | Realtor | 2 |
| David Andrews | Michael Piper | 2 |
| Erik Stolhanske | Man on Boat | 2 |
| Christine Estabrook | Emily Previn | 2 |
| Matt Ross | Daniel Showalter | 2 |
| Joe Nieves | Construction Worker #1 | 2 |
| Sandra Oh | Porn Starlet | 2 |
| Brian Stepanek | Alex Graham | 2 |
| Elizabeth Rodriguez | Sylvie | 2 |
| Zachary Quinto | Hip Student | 2 |
| Nan Martin | Rita Piper | 2 |
| Joel McKinnon Miller | Tuttle Friend with Flattop | 2 |
| Cynthia Stevenson | Joy Solomon | 2 |
| Stanley Kamel | Death | 2 |
| Hallee Hirsh | Kaitlin Stolte | 2 |
| Mageina Tovah | Pink-Haired Girl | 2 |
| Julia Vera | Cleaning Woman | 2 |
| Mark L. Taylor | Mr. Stolte | 2 |
| Tuc Watkins | Trevor | 2 |
| Diane Delano | Teri | 2 |
| Julianna McCarthy | Beatrice | 2 |
| Lori Alan | Macy's Saleswoman | 2 |
| Kim Myers | Dr. Michaelson | 2 |
| Jeremy Roberts | Callie's Friend #2 | 2 |
| Travis Wester | Henry | 2 |
| Christina Cabot | Hiking Woman | 2 |
| Jenna Boyd | 7-Year-Old Girl | 2 |
| Mo Collins | Nancy Freymire | 2 |
| Dennis Christopher | Kevin Lamb | 2 |
| Andy Milder | Julio's Principal | 2 |
| Tom Lenk | Young Poet | 2 |
| Cullen Douglas | Mr. Clarington | 2 |
| Lombardo Boyar | Powerful | 2 |
| Dave Power | Nolan | 2 |
| Maury Sterling | Pot Dealer | 2 |
| Gabriel Olds | Lauderbach | 2 |
| Lois Hall | Minister | 2 |
| Stanley DeSantis | Peter Burns | 2 |
| Angela Goethals | Cindy | 2 |
| Cristine Rose | Hannah | 2 |
| Bob Morrisey | Dean Kekalos | 2 |
| Kenneth Kimmins | Crematory Owner | 2 |
| David Shatraw | Shiatsu Client | 2 |
| Ann Weldon | Aunt Jeanie | 2 |
| Victor Campos | Pilar's Father | 2 |
| Lee Weaver | James Dubois Marshall | 2 |
| Rusty Schwimmer | Marilyn Johnson | 2 |
| Jillian Armenante | Shirley | 2 |
| John Capodice | Tommy Romano | 2 |
| Deborah Theaker | Tour Guide | 2 |
| Julie Brown | Sissy Pasquese | 2 |
| Larry Drake | Inspector Gerson | 2 |
| Shashawnee Hall | Richard Langmead | 2 |
| Daniel Zacapa | Mr. Suarez, Jr. | 2 |
| Julie Ariola | Dorothy Milne | 2 |
| Brad Greenquist | Building Manager | 2 |
| Maggie Baird | Andrea Kuhn | 2 |
| Mary Gross | Floral Instructor | 2 |
| Judith Baldwin | Paula Mortimer | 2 |
| Gloria Garayua | Agnes | 2 |
| Rick Overton | Thomas Sheedy | 2 |
| Michele Greene | Dr. Fraker | 2 |
| Kate McGregor-Stewart | Andrea's Therapist | 2 |
| Berlinda Tolbert | Debra | 2 |
| Elayn J. Taylor | Nurse #1 | 2 |
| Elizabeth Ruscio | Madeleine Burns | 2 |
| Jennifer Darling | Edie's Mother (voice) | 2 |
| Lisa K. Wyatt | Pam, Kroehner Mortician | 2 |
| Adam Nelson | Match-Lighting Guy | 2 |
| Steve Ryan | Matthew Heath Collins | 2 |
| Ivonne Coll | Vanessa's Therapist | 2 |
| Beverly Leech | Mavis Spencer | 2 |
| Jed Allan | Dr. Gareth Feinberg | 2 |
| Dan Desmond | Art Teacher | 2 |
| Brent Roam | Man in Elevator | 2 |
| Marty Belafsky | Bakery Worker | 2 |
| Scott Burkholder | Kenneth Henderson | 2 |
| Lauri Johnson | Joan Morrison | 2 |
| Ethel Ayler | Ellen | 2 |
| Ben Weber | Hiking Man | 2 |
| Marc Worden | Zach | 2 |
| Leeza Gibbons | Self | 2 |
| Elaine Kao | Courtney | 2 |
| Rappin' Granny | 2 | |
| Bruce Wright | Detective | 2 |
| Roger Velasco | Young Man With Tattoos | 2 |
| Christina Carlisi | Judy Romano | 2 |
| David Ackert | Truck Driver | 2 |
| Amy Spanger | Holly Duncan | 2 |
| Jerry Hauck | Stan | 2 |
| Jean Carol | Wife #5 | 2 |
| Christine Mourad | Coco Gorodetsky | 2 |
| Chris Harrison | Self | 2 |
| Shawn Michael Patrick | Coroner | 2 |
| Ted Marcoux | Sam Finelli | 2 |
| Magda Harout | Anahid's Mother | 2 |
| Hansford Rowe | Harold Mossback | 2 |
| Amy Wheaton | Female Student | 2 |
| Cleo King | Life | 2 |
| Ellen Albertini Dow | Roberta | 2 |
| Marina Black | Parisian Classmate | 1 |
| Josh Radnor | Will Jaffe | 1 |
| Ellen DeGeneres | Ellen DeGeneres | 1 |
| Van Epperson | Angry Man | 1 |
| Hayden Tank | Young Nate | 1 |
| Gary Hershberger | Kroehner Representative | 1 |
| Danielle Petty | Waitress (uncredited) | 1 |
| Sarah Rafferty | Rachel Mortimer | 1 |
| Mandy June Turpin | Crying Woman | 1 |
| Sharon Madden | Woman Mourner | 1 |
| Paul Cassell | Evan | 1 |
| Ricardo Mamood-Vega | Hospital Orderly (uncredited) | 1 |
| Amanda Leighton | Singing Cactus Kid (uncredited) | 1 |
| Sara Mornell | Jessica Shapiro | 1 |
| Dina Spybey-Waters | Chatty Mourner | 1 |
| Jennifer Griffin | Crying Sicilian Daughter | 1 |
| Ben Scott | Butcher | 1 |
| Wilda Taylor | Ramona Kippleman | 1 |
| Rachel Zeskind | Nate's Ex-Girlfriend (uncredited) | 1 |
| Paul Hayes | Joe Marti | 1 |
| Claudette Sutherland | Cynthia Showalter | 1 |
| Michael Cornacchia | Lawrence Tuttle | 1 |
| Mary Kathleen Gordon | Wife #6 | 1 |
| Dagney Kerr | Patty | 1 |
| Brandon Dean | Eric | 1 |
| Veronica Hart | Jean Louise McArthur | 1 |