| Twitch City is a surreal sitcom set in the Toronto, Ontario neighbourhood of Kensington Market, and follows Curtis, a television addict who refuses to leave his apartment, and his friends and roommates Nathan and Hope. In the series' first episode, Nathan is sent to prison for killing a homeless man with a can of cat food, leaving Curtis and Hope to find a replacement roommate to help with the rent. |
| Name | Character | Episodes |
|---|---|---|
| Molly Parker | Hope | 13 |
| Don McKellar | Curtis | 13 |
| Daniel MacIvor | Nathan | 13 |
| Callum Keith Rennie | Newbie | 6 |
| Bruce McCulloch | Rex Reilly | 6 |
| Kenneth Welsh | Mr. Surdjic | 2 |
| Jonathan Potts | Lawrence | 2 |
| Kris Lemche | Clinton | 2 |
| Tracy Wright | Dizelle | 2 |
| Raoul Bhaneja | Fred | 2 |
| Al Waxman | Homeless Man | 2 |
| Valerie Buhagiar | Lucky (voice) | 2 |
| Jennifer Jason Leigh | Faith | 1 |
| Peter Mensah | Prison Guard | 1 |
| Joyce DeWitt | Self | 1 |
| Joe Pingue | Italian Man | 1 |
| Joe Pingue | Greg | 1 |
| Martin Roach | Bad Cop | 1 |
| Martin Roach | Sharpshooter 1 | 1 |
| Sergio Di Zio | Jim | 1 |
| Sherry Miller | Wendy | 1 |
| Landy Cannon | Rob Quartly | 1 |
| Laura Bertram | Babe | 1 |
| Hugh Dillon | Guy in the Convenience Store (uncredited) | 1 |
| Hugh Dillon | Howard the Cannibal | 1 |
| Jayne Eastwood | Nathan's Mother | 1 |
| Mary Long | Young Woman | 1 |
| Maurice Dean Wint | Taylor | 1 |
| Kedar Brown | Warm-Up Guy | 1 |
| Amos Crawley | Musician 1 | 1 |
| Darren Moore | Physicist | 1 |
| R.D. Reid | Mr. Caine | 1 |
| Michael DeCarlo | Producer | 1 |
| Alex Karzis | Dude | 1 |
| Ho Chow | Chinese Assistant | 1 |
| Stefan Brogren | Tyler Fawcett | 1 |
| Catherine Fitch | Ellen | 1 |
| Jennifer Whalen | Happy Light Woman | 1 |
| Oscar Hsu | Chinese Businessman | 1 |
| Timm Zemanek | White Collar Criminal | 1 |
| Joyce Gordon | Eleanor Nanibush | 1 |
| Nicholas Rice | Relationship Man | 1 |
| John L'Ecuyer | Articling Student | 1 |
| Semi Chellas | Audience Member | 1 |
| Semi Chellas | Victoria | 1 |
| Robert King | Andrew | 1 |
| Charmion King | Meals Lady | 1 |
| Tom McCamus | Dean | 1 |
| Jessica Booker | Mechanic Woman | 1 |