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| Barangay 143 follows the coming of age story of a young man in search of a father and how he finds an unlikely family in a team of misfits trying to bring glory to their hometown. It's a story about love and family set against the action-packed world of street basketball, where the stakes are always high and life is the biggest game you can win. |
| Name | Character | Episodes |
|---|---|---|
| Lorna Tolentino | Tita Baby (Kapitana Baby Dela Cruz) (voice) | 26 |
| Jerald Napoles | Chikoy Poh (voice) | 26 |
| Archie Alemania | Shugo Sikat (voice) | 26 |
| Antonio Aquitania | Norman Nazareno (voice) | 26 |
| Edu Manzano | Commissioner Jack Rivera ("Jumping" Jack Rivera) (voice) | 26 |
| John Arcilla | Coach B (Roberto "Bobby" Sebastián, Sr.) (voice) | 26 |
| Benjie Paras | Abdul Salik (voice) | 26 |
| Paolo Contis | Koboy Guerrero (voice) | 26 |
| Jaime Fabregas | Coach Caloy (voice) | 14 |